Phenotypes associated with this allele

• Allele Symbol: Ikbkb^M1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5691958
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ikbkb^M1Btlr/Ikbkb^M1Btlr	C57BL/6J-Ikbkb^M1Btlr	MGI:5691989
ht2	Ikbkb^M1Btlr/Ikbkb^+	C57BL/6J-Ikbkb^M1Btlr	MGI:5691988

Genotype
MGI:5691989

hm1

• Allelic Composition: Ikbkb^M1Btlr/Ikbkb^M1Btlr
• Genetic Background: C57BL/6J-Ikbkb^M1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225271 )

• mice exhibit an increase in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of peripheral CD8+ T cells in CD3 T cells after MCMV infection

abnormal B cell physiology ( J:225271 )

• some mice exhibit a reduced frequency of B1a cells in B1 cells and an increased frequency of B1b cells in B1 cells

increased susceptibility to viral infection ( J:225271 )

hematopoietic system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225271 )

• mice exhibit an increase in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of peripheral CD8+ T cells in CD3 T cells after MCMV infection

abnormal B cell physiology ( J:225271 )

• some mice exhibit a reduced frequency of B1a cells in B1 cells and an increased frequency of B1b cells in B1 cells

Genotype
MGI:5691988

ht2

• Allelic Composition: Ikbkb^M1Btlr/Ikbkb⁺
• Genetic Background: C57BL/6J-Ikbkb^M1Btlr

immune system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225271 )

• mice exhibit an increase in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of peripheral CD8+ T cells in CD3 T cells after MCMV infection

abnormal B cell physiology ( J:225271 )

• some mice exhibit a reduced frequency of B1a cells in B1 cells and an increased frequency of B1b cells in B1 cells in the peripheral blood after MCMV infection

abnormal response to infection ( J:225271 )

• after MCMV infection, mice exhibit an increase in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of peripheral CD8+ T cells in CD3 T cells and some mice exhibit a reduced frequency of B1a cells in B1 cells and an increased frequency of B1b cells in B1 cells in the peripheral blood

increased response to antigen ( J:225271 )

• mice exhibit impaired IgE and IgG1 responses to the cysteine protease papain

hematopoietic system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225271 )

• mice exhibit an increase in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of peripheral CD8+ T cells in CD3 T cells after MCMV infection

abnormal B cell physiology ( J:225271 )

• some mice exhibit a reduced frequency of B1a cells in B1 cells and an increased frequency of B1b cells in B1 cells in the peripheral blood after MCMV infection