cellular
• progressive reduction of primordial oocytes as compared to controls
• oocyte numbers are similar to controls at 10 days of age, but drop to 20% of controls at 14 months
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reproductive system
• progressive reduction of primordial oocytes as compared to controls
• oocyte numbers are similar to controls at 10 days of age, but drop to 20% of controls at 14 months
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• number of primary follicles is reduced at 12 months of age as compared to controls
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• number of primordial follicles is reduced at 2 months, 8 months and 12 months as compared to controls
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• number of secondary follicles is reduced at 12 months of age as compared to controls
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• females show accelerated reproductive aging
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• litter sizes are reduced , however number of litters is similar to controls
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mortality/aging
• females show accelerated reproductive aging
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endocrine/exocrine glands
• number of primary follicles is reduced at 12 months of age as compared to controls
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• number of primordial follicles is reduced at 2 months, 8 months and 12 months as compared to controls
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• number of secondary follicles is reduced at 12 months of age as compared to controls
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