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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eef1a1tm1Tcrl
targeted mutation 1, Thomas Carroll
MGI:5692071
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Eef1a1tm1Tcrl/Eef1a1tm1Tcrl involves: 129S6/SvEvTac * C57BL/6 MGI:5692454
cn2
 		Eef1a1tm1Tcrl/Eef1a1+
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:5692456


Genotype
MGI:5692454
hm1
Allelic
Composition		 Eef1a1tm1Tcrl/Eef1a1tm1Tcrl
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1tm1Tcrl mutation (0 available); any Eef1a1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, complete penetrance ( J:225273 )
• female mice are not viable




Genotype
MGI:5692456
cn2
Allelic
Composition		 Eef1a1tm1Tcrl/Eef1a1+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Eef1a1tm1Tcrl mutation (0 available); any Eef1a1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
open neural tube ( J:225273 )
• a high percentage of E12.5 embryos exhibit neural tube defects
spina bifida ( J:225273 )
• several E11.5 and E12.5 embryos exhibit spina bifida

mortality/aging
postnatal lethality, complete penetrance ( J:225273 )
• no pups survive beyond P14
lethality throughout fetal growth and development, incomplete penetrance ( J:225273 )
• fewer double heterozygous animals (4.6%) are produced than expected (25%) from a heterozygote x heterozygote mating
• a significant drop in viability occurs between E15.5 and birth

nervous system
open neural tube ( J:225273 )
• a high percentage of E12.5 embryos exhibit neural tube defects
spina bifida ( J:225273 )
• several E11.5 and E12.5 embryos exhibit spina bifida
holoprosencephaly ( J:225273 )
• several E11.5 and E12.5 embryos exhibit holoprosencephaly




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory