Phenotypes associated with this allele

• Allele Symbol: Rock2^tm1Zpj
• Allele Name: targeted mutation 1, Zhengping Jia
• Allele ID: MGI:5692187
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rock2^tm1Zpj/Rock2^tm1Zpj	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:5692191
ht2	Rock2^tm1Zpj/Rock2^+	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:5692192

Genotype
MGI:5692191

hm1

• Allelic Composition: Rock2^tm1Zpj/Rock2^tm1Zpj
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:225274 )

N • mice exhibit normal brain anatomy, NMDA- or APMPA-excitatory postsynaptic currents, number and total length of dendrites and axonal growth

increased dendritic spine length ( J:225274 )

• spine length is increased with deficits in the actin cytoskeleton and cofilin compared to in wild-type mice

abnormal synapse morphology ( J:225274 )

• reduced density of asymmetric synapses with increased postsynaptic area or spine area

abnormal excitatory postsynaptic potential ( J:225274 )

• reduced field excitatory postsynaptic potentials over a wide range of stimulation intensities

reduced long-term potentiation ( J:225274 )

• induced by high frequency stimulation

• however, long-term depression induced by application of metabotropic glutamate receptor agonist (RS)-3,5-DHPG

decreased paired-pulse facilitation ( J:225274 )

• mild deficit, only at 25 ms interpulse interval points

cellular

abnormal actin cytoskeleton morphology ( J:225274 )

• dendritic spine length is increased with deficits in the actin cytoskeleton and cofilin compared to in wild-type mice

Genotype
MGI:5692192

ht2

• Allelic Composition: Rock2^tm1Zpj/Rock2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:224630 )

N • mice fed normal chow or a high-fat diet exhibit normal fasting blood glucose levels and cardiac triglyceride levels

decreased susceptibility to diet-induced obesity ( J:224630 )

• mice fed a high-fat diet exhibit slightly less weight gain compared with wild-type mice

abnormal circulating cholesterol level ( J:224630 )

• mice fed a high-fat diet do not exhibit an increase in serum cholesterol unlike wild-type mice

decreased circulating free fatty acids level ( J:224630 )

• lower in mice fed a high-fat diet compared with mice fed standard chow

improved glucose tolerance ( J:224630 )

• mice fed a high-fat diet exhibit improved insulin tolerance compared with wild-type mice

cardiovascular system

abnormal cardiovascular system morphology ( J:224630 )

• mice fed a high-fat diet exhibit normal heart weight, left ventricular mass and left ventricular end-diastolic internal diameter unlike wild-type mice

abnormal cardiovascular system physiology ( J:224630 )

• mice fed a high-fat diet do not exhibit a change in cardiac function unlike wild-type mice

growth/size/body

growth/size/body region phenotype ( J:224630 )

N • mice fed normal chow exhibit normal body weight

decreased susceptibility to diet-induced obesity ( J:224630 )

• mice fed a high-fat diet exhibit slightly less weight gain compared with wild-type mice