Phenotypes associated with this allele

• Allele Symbol: Cnih4^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5692513
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnih4^tm1a(EUCOMM)Hmgu/Cnih4^tm1a(EUCOMM)Hmgu	involves: C57BL/6N	MGI:7437739

Genotype
MGI:7437739

hm1

• Allelic Composition: Cnih4^{tm1a(EUCOMM)Hmgu}/Cnih4^{tm1a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N
• Cell Lines: HEPD0683_2_B06

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:333288 )

N • adult females are fertile and show normal ovarian size and histology, with no detectable defects in oogenesis

N • despite mild defects in sperm number, motility and morphology, adult males are fertile with no detectable defects in testes to body weight ratio, testicular histology or meiotic progression, indicating normal spermatogenesis

oligozoospermia ( J:333288 )

♂ • the number of spermatozoa per cauda epididymis is slightly lower than that in wild-type controls

teratozoospermia ( J:333288 )

♂ • the percentage of spermatozoa with normal morphology is slightly lower than that in wild-type controls

asthenozoospermia ( J:333288 )

♂ • CASA analysis showed a significant reduction in the % of motile sperm

♂ • however, the % of progressively motile sperm is comparable to that in wild-type controls

cellular

oligozoospermia ( J:333288 )

♂ • the number of spermatozoa per cauda epididymis is slightly lower than that in wild-type controls

teratozoospermia ( J:333288 )

♂ • the percentage of spermatozoa with normal morphology is slightly lower than that in wild-type controls

asthenozoospermia ( J:333288 )

♂ • CASA analysis showed a significant reduction in the % of motile sperm

♂ • however, the % of progressively motile sperm is comparable to that in wild-type controls