Phenotypes associated with this allele

• Allele Symbol: Cyp7a1^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5692562
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp7a1^tm1b(EUCOMM)Wtsi/Cyp7a1^tm1b(EUCOMM)Wtsi	C57BL/6N-Cyp7a1^tm1b(EUCOMM)Wtsi/Ieg	MGI:6262243

Genotype
MGI:6262243

hm1

• Allelic Composition: Cyp7a1^{tm1b(EUCOMM)Wtsi}/Cyp7a1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Cyp7a1^{tm1b(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0426_3_C04

Data Sources

IMPC Data for Cyp7a1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:211773 )

IMPC - HMGU

increased startle reflex ( J:211773 )

♀

IMPC - HMGU

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

IMPC - HMGU

abnormal retina blood vessel morphology ( J:211773 )

IMPC - HMGU

hematopoietic system

increased leukocyte cell number ( J:211773 )

♀

IMPC - HMGU

homeostasis/metabolism

decreased blood urea nitrogen level ( J:211773 )

♀

IMPC - HMGU

increased circulating bilirubin level ( J:211773 )

♀

IMPC - HMGU

increased circulating cholesterol level ( J:211773 )

IMPC - HMGU

increased circulating HDL cholesterol level ( J:211773 )

IMPC - HMGU

decreased circulating iron level ( J:211773 )

♀

IMPC - HMGU

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - HMGU

decreased circulating serum albumin level ( J:211773 )

♂

IMPC - HMGU

increased circulating unsaturated transferrin level ( J:211773 )

♂

IMPC - HMGU

immune system

increased leukocyte cell number ( J:211773 )

♀

IMPC - HMGU

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - HMGU

cataract ( J:211773 )

IMPC - HMGU

abnormal retina morphology ( J:211773 )

IMPC - HMGU

abnormal retina vasculature morphology ( J:211773 )

IMPC - HMGU

abnormal retina blood vessel morphology ( J:211773 )

IMPC - HMGU

abnormal vitreous body morphology ( J:211773 )

IMPC - HMGU

persistence of hyaloid vascular system ( J:211773 )

♀

IMPC - HMGU