Phenotypes associated with this allele

• Allele Symbol: Itch^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5692595
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itch^tm1b(EUCOMM)Hmgu/Itch^tm1b(EUCOMM)Hmgu	C57BL/6N-Itch^tm1b(EUCOMM)Hmgu/H	MGI:5797608

Genotype
MGI:5797608

hm1

• Allelic Composition: Itch^{tm1b(EUCOMM)Hmgu}/Itch^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Itch^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0706_7_E10

Data Sources

IMPC Data for Itch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

♀

IMPC - HAR

behavior/neurological

decreased exploration in new environment ( J:211773 )

IMPC - HAR

abnormal startle reflex ( J:211773 )

♂

IMPC - HAR

tremors ( J:211773 )

♀

IMPC - HAR

cardiovascular system

increased heart weight ( J:211773 )

♀

IMPC - HAR

craniofacial

abnormal tooth morphology ( J:211773 )

♂

IMPC - HAR

digestive/alimentary system

abnormal esophagus morphology ( J:211773 )

♀

IMPC - HAR

endocrine/exocrine glands

enlarged gallbladder ( J:211773 )

♀

IMPC - HAR

growth/size/body

increased heart weight ( J:211773 )

♀

IMPC - HAR

abnormal tooth morphology ( J:211773 )

♂

IMPC - HAR

enlarged gallbladder ( J:211773 )

♀

IMPC - HAR

increased lean body mass ( J:211773 )

♀

IMPC - HAR

abnormal head size ( J:211773 )

♂

IMPC - HAR

enlarged kidney ( J:211773 )

♀

IMPC - HAR

enlarged spleen ( J:211773 )

♀

IMPC - HAR

increased spleen weight ( J:211773 )

IMPC - HAR

hematopoietic system

enlarged spleen ( J:211773 )

♀

IMPC - HAR

increased spleen weight ( J:211773 )

IMPC - HAR

decreased hematocrit ( J:211773 )

♀

IMPC - HAR

decreased hemoglobin content ( J:211773 )

IMPC - HAR

decreased mean corpuscular hemoglobin ( J:211773 )

♀

IMPC - HAR

decreased mean corpuscular volume ( J:211773 )

♀

IMPC - HAR

increased red blood cell distribution width ( J:211773 )

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♀

IMPC - HAR

increased leukocyte cell number ( J:211773 )

IMPC - HAR

increased basophil cell number ( J:211773 )

IMPC - HAR

increased eosinophil cell number ( J:211773 )

IMPC - HAR

increased neutrophil cell number ( J:211773 )

IMPC - HAR

increased lymphocyte cell number ( J:211773 )

IMPC - HAR

increased large unstained cell number ( J:211773 )

IMPC - HAR

homeostasis/metabolism

increased blood urea nitrogen level ( J:211773 )

♀

IMPC - HAR

decreased circulating fructosamine level ( J:211773 )

♀

IMPC - HAR

decreased circulating glucose level ( J:211773 )

IMPC - HAR

decreased fasting circulating glucose level ( J:211773 )

♂

IMPC - HAR

increased circulating calcium level ( J:211773 )

♀

IMPC - HAR

increased circulating phosphate level ( J:211773 )

♀

IMPC - HAR

decreased circulating alkaline phosphatase level ( J:211773 )

IMPC - HAR

increased circulating amylase level ( J:211773 )

IMPC - HAR

increased circulating aspartate transaminase level ( J:211773 )

♀

IMPC - HAR

increased circulating total protein level ( J:211773 )

♀

IMPC - HAR

immune system

enlarged spleen ( J:211773 )

♀

IMPC - HAR

increased spleen weight ( J:211773 )

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♀

IMPC - HAR

increased leukocyte cell number ( J:211773 )

IMPC - HAR

increased basophil cell number ( J:211773 )

IMPC - HAR

increased eosinophil cell number ( J:211773 )

IMPC - HAR

increased neutrophil cell number ( J:211773 )

IMPC - HAR

increased lymphocyte cell number ( J:211773 )

IMPC - HAR

increased large unstained cell number ( J:211773 )

IMPC - HAR

liver/biliary system

enlarged gallbladder ( J:211773 )

♀

IMPC - HAR

renal/urinary system

enlarged kidney ( J:211773 )

♀

IMPC - HAR

skeleton

abnormal tooth morphology ( J:211773 )

♂

IMPC - HAR

abnormal bone structure ( J:211773 )

♀

IMPC - HAR

decreased bone mineral content ( J:211773 )

IMPC - HAR

decreased bone mineral density ( J:211773 )

♀

IMPC - HAR