Phenotypes associated with this allele

• Allele Symbol: Epc2^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5692601
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epc2^tm1b(EUCOMM)Wtsi/Epc2^tm1b(EUCOMM)Wtsi	C57BL/6N-Epc2^tm1b(EUCOMM)Wtsi/Ieg	MGI:5757054
ht2	Epc2^tm1b(EUCOMM)Wtsi/Epc2^+	C57BL/6N-Epc2^tm1b(EUCOMM)Wtsi/Ieg	MGI:5757053

Genotype
MGI:5757054

hm1

• Allelic Composition: Epc2^{tm1b(EUCOMM)Wtsi}/Epc2^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Epc2^{tm1b(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0018_2_G10

Data Sources

IMPC Data for Epc2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:5757053

ht2

• Allelic Composition: Epc2^{tm1b(EUCOMM)Wtsi}/Epc2⁺
• Genetic Background: C57BL/6N-Epc2^{tm1b(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0018_2_G10

Data Sources

IMPC Data for Epc2

behavior/neurological

abnormal behavior ( J:211773 )

♂

IMPC - HMGU

increased thigmotaxis ( J:211773 )

♂

IMPC - HMGU

decreased locomotor activity ( J:211773 )

♂

IMPC - HMGU

cardiovascular system

abnormal retina blood vessel morphology ( J:211773 )

♂

IMPC - HMGU

homeostasis/metabolism

increased respiratory quotient ( J:211773 )

♀

IMPC - HMGU

respiratory system

increased pulmonary respiratory rate ( J:211773 )

IMPC - HMGU

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - HMGU

cataract ( J:211773 )

♂

IMPC - HMGU

abnormal retina morphology ( J:211773 )

♀

IMPC - HMGU

abnormal retina blood vessel morphology ( J:211773 )

♂

IMPC - HMGU

decreased total retina thickness ( J:211773 )

IMPC - HMGU