Phenotypes associated with this allele

• Allele Symbol: Emc8^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5692625
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Emc8^tm1b(EUCOMM)Hmgu/Emc8^tm1b(EUCOMM)Hmgu	C57BL/6N-Emc8^tm1b(EUCOMM)Hmgu/H	MGI:6262369
ht2	Emc8^tm1b(EUCOMM)Hmgu/Emc8^+	C57BL/6N-Emc8^tm1b(EUCOMM)Hmgu/H	MGI:5797506

Genotype
MGI:6262369

hm1

• Allelic Composition: Emc8^{tm1b(EUCOMM)Hmgu}/Emc8^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Emc8^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0711_2_B02

Data Sources

IMPC Data for Emc8

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:5797506

ht2

• Allelic Composition: Emc8^{tm1b(EUCOMM)Hmgu}/Emc8⁺
• Genetic Background: C57BL/6N-Emc8^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0711_2_B02

Data Sources

IMPC Data for Emc8

adipose tissue

increased total body fat amount ( J:211773 )

♀

IMPC - HAR

cardiovascular system

abnormal retina blood vessel morphology ( J:211773 )

♂

IMPC - HAR

enlarged heart ( J:211773 )

♂

IMPC - HAR

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - HAR

decreased lean body mass ( J:211773 )

♀

IMPC - HAR

hematopoietic system

increased red blood cell distribution width ( J:211773 )

♂

IMPC - HAR

increased neutrophil cell number ( J:211773 )

♂

IMPC - HAR

immune system

increased neutrophil cell number ( J:211773 )

♂

IMPC - HAR

vision/eye

abnormal retina blood vessel morphology ( J:211773 )

♂

IMPC - HAR

mydriasis ( J:211773 )

♂

IMPC - HAR