Phenotypes associated with this allele

• Allele Symbol: Slc25a1^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5692627
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc25a1^tm1b(EUCOMM)Wtsi/Slc25a1^tm1b(EUCOMM)Wtsi	C57BL/6N-Slc25a1^tm1b(EUCOMM)Wtsi/Bay	MGI:6263489
ht2	Slc25a1^tm1b(EUCOMM)Wtsi/Slc25a1^+	C57BL/6N-Slc25a1^tm1b(EUCOMM)Wtsi/Bay	MGI:6288727

Genotype
MGI:6263489

hm1

• Allelic Composition: Slc25a1^{tm1b(EUCOMM)Wtsi}/Slc25a1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Slc25a1^{tm1b(EUCOMM)Wtsi}/Bay
• Cell Lines: EPD0336_2_D03

Data Sources

IMPC Data for Slc25a1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal craniofacial morphology ( J:211773 )

IMPC - BCM

abnormal cranium morphology ( J:211773 )

IMPC - BCM

abnormal facial morphology ( J:211773 )

IMPC - BCM

protruding tongue ( J:211773 )

IMPC - BCM

facial cleft ( J:211773 )

IMPC - BCM

abnormal head shape ( J:211773 )

IMPC - BCM

digestive/alimentary system

protruding tongue ( J:211773 )

IMPC - BCM

embryo

abnormal embryo development ( J:211773 )

IMPC - BCM

embryonic growth retardation ( J:211773 )

IMPC - BCM

abnormal embryo size ( J:211773 )

IMPC - BCM

abnormal neural tube closure ( J:211773 )

IMPC - BCM

growth/size/body

abnormal facial morphology ( J:211773 )

IMPC - BCM

protruding tongue ( J:211773 )

IMPC - BCM

facial cleft ( J:211773 )

IMPC - BCM

abnormal head shape ( J:211773 )

IMPC - BCM

embryonic growth retardation ( J:211773 )

IMPC - BCM

abnormal embryo size ( J:211773 )

IMPC - BCM

abnormal head size ( J:211773 )

IMPC - BCM

hearing/vestibular/ear

abnormal ear morphology ( J:211773 )

IMPC - BCM

integument

pallor ( J:211773 )

IMPC - BCM

limbs/digits/tail

abnormal limb morphology ( J:211773 )

IMPC - BCM

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM

nervous system

abnormal neural tube closure ( J:211773 )

IMPC - BCM

abnormal forebrain morphology ( J:211773 )

IMPC - BCM

abnormal hindbrain morphology ( J:211773 )

IMPC - BCM

exencephaly ( J:211773 )

IMPC - BCM

skeleton

abnormal cranium morphology ( J:211773 )

IMPC - BCM

vision/eye

anophthalmia ( J:211773 )

♀

IMPC - BCM

Genotype
MGI:6288727

ht2

• Allelic Composition: Slc25a1^{tm1b(EUCOMM)Wtsi}/Slc25a1⁺
• Genetic Background: C57BL/6N-Slc25a1^{tm1b(EUCOMM)Wtsi}/Bay
• Cell Lines: EPD0336_2_D03

Data Sources

IMPC Data for Slc25a1

behavior/neurological

increased exploration in new environment ( J:211773 )

♀

IMPC - BCM

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

IMPC - BCM

vision/eye

abnormal retina vasculature morphology ( J:211773 )

IMPC - BCM