Phenotypes associated with this allele

• Allele Symbol: Alg14^{tm2b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 2b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5692664
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Alg14^tm2b(EUCOMM)Hmgu/Alg14^tm2b(EUCOMM)Hmgu	C57BL/6N-Alg14^tm2b(EUCOMM)Hmgu/Bay	MGI:6261839
ht2	Alg14^tm2b(EUCOMM)Hmgu/Alg14^+	C57BL/6N-Alg14^tm2b(EUCOMM)Hmgu/Bay	MGI:6461055

Genotype
MGI:6261839

hm1

• Allelic Composition: Alg14^{tm2b(EUCOMM)Hmgu}/Alg14^{tm2b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Alg14^{tm2b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0817_2_A10

Data Sources

IMPC Data for Alg14

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Alg14^{tm2b(EUCOMM)Hmgu}/Alg14^{tm2b(EUCOMM)Hmgu} mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but no embryos at E7.5. Blastocysts fail to hatch from the zona pellucida an appear necrotic after 72 hours in culture.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro, blastocysts fail to hatch from the zona pellucida and appear necrotic after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - BCM

embryonic lethality at implantation ( J:279207 )

• normal looking blastocysts are present in approximate Mendelian ratios at E3.5 (42% versus expected 25%, n=26); no embryos or excess resorption sites are recovered at E7.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM

Genotype
MGI:6461055

ht2

• Allelic Composition: Alg14^{tm2b(EUCOMM)Hmgu}/Alg14⁺
• Genetic Background: C57BL/6N-Alg14^{tm2b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0817_2_A10

Data Sources

IMPC Data for Alg14

vision/eye

increased cornea thickness ( J:211773 )

♂

IMPC - BCM