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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ddrgk1tm1b(EUCOMM)Hmgu
targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
MGI:5692746
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ddrgk1tm1b(EUCOMM)Hmgu/Ddrgk1tm1b(EUCOMM)Hmgu C57BL/6N-Ddrgk1tm1b(EUCOMM)Hmgu/Rbrc MGI:5813002
hm2
Ddrgk1tm1b(EUCOMM)Hmgu/Ddrgk1tm1b(EUCOMM)Hmgu involves: C57BL/6N MGI:5897611


Genotype
MGI:5813002
hm1
Allelic
Composition
Ddrgk1tm1b(EUCOMM)Hmgu/Ddrgk1tm1b(EUCOMM)Hmgu
Genetic
Background
C57BL/6N-Ddrgk1tm1b(EUCOMM)Hmgu/Rbrc
Cell Lines HEPD0618_2_D03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddrgk1tm1b(EUCOMM)Hmgu mutation (1 available); any Ddrgk1 mutation (21 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5897611
hm2
Allelic
Composition
Ddrgk1tm1b(EUCOMM)Hmgu/Ddrgk1tm1b(EUCOMM)Hmgu
Genetic
Background
involves: C57BL/6N
Cell Lines HEPD0618_2_D02
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddrgk1tm1b(EUCOMM)Hmgu mutation (1 available); any Ddrgk1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice died at E12.5 and all mice are dead by E13.5

hematopoietic system
• reduced colony-forming units-granulocyte/macrophage and colony-forming units-granulocyte/erythrocyte/macrophage/megakaryocyte in E11.5 fetal livers
• fewer peripheral circulating erythrocytes at E11.5
• large number of abnormal multinucleated erythroid cells with some exhibiting cell death
• impaired with a blocked differentiation of TER1119low into TER119med+high cells

cellular
• extensive in the brain (fourth ventricle at E11.5), liver and other tissues (duodenum lumen at E11.5)

embryo
• most mice died at E12.5 and all mice are dead by E13.5
• impaired with a blocked differentiation of TER1119low into TER119med+high cells

growth/size/body
• most mice died at E12.5 and all mice are dead by E13.5

integument
• at E11.5

liver/biliary system
• small and disorganized with reduced cellularity and increased cell death at E11.5





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory