Phenotypes associated with this allele

• Allele Symbol: Mbd5^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5692774
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mbd5^tm1b(EUCOMM)Wtsi/Mbd5^tm1b(EUCOMM)Wtsi	C57BL/6N-Mbd5^tm1b(EUCOMM)Wtsi/Ics	MGI:6262849
ht2	Mbd5^tm1b(EUCOMM)Wtsi/Mbd5^+	C57BL/6N-Mbd5^tm1b(EUCOMM)Wtsi/Ics	MGI:5757346

Genotype
MGI:6262849

hm1

• Allelic Composition: Mbd5^{tm1b(EUCOMM)Wtsi}/Mbd5^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Mbd5^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0056_1_E03

Data Sources

IMPC Data for Mbd5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - ICS

Genotype
MGI:5757346

ht2

• Allelic Composition: Mbd5^{tm1b(EUCOMM)Wtsi}/Mbd5⁺
• Genetic Background: C57BL/6N-Mbd5^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0056_1_E03

Data Sources

IMPC Data for Mbd5

behavior/neurological

decreased exploration in new environment ( J:211773 )

♂

IMPC - ICS

decreased locomotor activity ( J:211773 )

IMPC - ICS

craniofacial

abnormal lip morphology ( J:211773 )

♀

IMPC - ICS

growth/size/body

abnormal lip morphology ( J:211773 )

♀

IMPC - ICS

hematopoietic system

decreased leukocyte cell number ( J:211773 )

♂

IMPC - ICS

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - ICS

immune system

decreased leukocyte cell number ( J:211773 )

♂

IMPC - ICS

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - ICS

limbs/digits/tail

short tibia ( J:211773 )

♂

IMPC - ICS

skeleton

short tibia ( J:211773 )

♂

IMPC - ICS

vision/eye

decreased total retina thickness ( J:211773 )

♂

IMPC - ICS