Phenotypes associated with this allele

• Allele Symbol: Aph1a^{tm1b(KOMP)Mbp}
• Allele Name: targeted mutation 1b, Mouse Biology Program, UC Davis
• Allele ID: MGI:5692808
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aph1a^tm1b(KOMP)Mbp/Aph1a^tm1b(KOMP)Mbp	C57BL/6N-Aph1a^tm1b(KOMP)Mbp/Bay	MGI:6261885
ht2	Aph1a^tm1b(KOMP)Mbp/Aph1a^+	C57BL/6N-Aph1a^tm1b(KOMP)Mbp/Bay	MGI:6288333

Genotype
MGI:6261885

hm1

• Allelic Composition: Aph1a^{tm1b(KOMP)Mbp}/Aph1a^{tm1b(KOMP)Mbp}
• Genetic Background: C57BL/6N-Aph1a^{tm1b(KOMP)Mbp}/Bay
• Cell Lines: DEPD00535_3_C11

Data Sources

IMPC Data for Aph1a

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryo size ( J:211773 )

IMPC - BCM

pale yolk sac ( J:211773 )

IMPC - BCM

growth/size/body

abnormal embryo size ( J:211773 )

IMPC - BCM

integument

pallor ( J:211773 )

IMPC - BCM

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - BCM

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM

Genotype
MGI:6288333

ht2

• Allelic Composition: Aph1a^{tm1b(KOMP)Mbp}/Aph1a⁺
• Genetic Background: C57BL/6N-Aph1a^{tm1b(KOMP)Mbp}/Bay
• Cell Lines: DEPD00535_3_C11

Data Sources

IMPC Data for Aph1a

behavior/neurological

hyperactivity ( J:211773 )

♀

IMPC - BCM

integument

abnormal coat appearance ( J:211773 )

♂

IMPC - BCM

abnormal skin coloration ( J:211773 )

IMPC - BCM

skeleton

increased bone mineral content ( J:211773 )

♂

IMPC - BCM

vision/eye

decreased total retina thickness ( J:211773 )

IMPC - BCM