Analysis Tools
normal phenotype
|
• mice are overtly normal and exhibit normal growth rates and intraperitoneal and oral glucose tolerance with no differences in glucose-induced Ca2+ dynamics or insulin secretion in isolated islets relative to control mice
• mutant islets show normal glucagon-like peptide-1 (GLP-1)-induced Ca2+ dynamics and insulin secretion, with a similar increase in GLP-1-induced Ca2+ oscillation frequency during moderate glucose stimulation relative to control islets
|
