Phenotypes associated with this allele

• Allele Symbol: Ric8b^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5692848
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Omp^tm4(cre)Mom/Omp^+ Ric8b^tm1c(EUCOMM)Hmgu/Ric8b^tm1c(EUCOMM)Hmgu	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL	MGI:6119583

Genotype
MGI:6119583

cn1

• Allelic Composition: Omp^tm4(cre)Mom/Omp⁺; Ric8b^{tm1c(EUCOMM)Hmgu}/Ric8b^{tm1c(EUCOMM)Hmgu}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:247954 )

• olfactory sensory neuron layer is thinner than control

decreased olfactory sensory neuron number ( J:247954 )

• number of OMP-positive olfactory neurons is decreased in epithelium, however, number of Olfr1507-positive neurons is not reduced

abnormal olfactory epithelium physiology ( J:247954 )

• cell death is 5X higher in olfactory epithelium than in controls

abnormal olfactory sensory neuron physiology ( J:247954 )

• olfactory neurons in vitro are unresponsive to an odorant mix

impaired olfaction ( J:247954 )

• in the buried-food-seeking test, mice take longer to locate food than controls

• in the odorant preference test, mice exhibit a reduced preference to milk and peanut butter relative to water

• mice do not exhibit avoidance behavior in response to the odorant butyric acid

mortality/aging

decreased survivor rate ( J:247954 )

• overall, 11% of homozygous pups survive rather than the expected 25%

postnatal lethality, incomplete penetrance ( J:247954 )

• some pups die immediately after birth, especially pups from a litter size greater than 6

craniofacial

abnormal olfactory sensory neuron morphology ( J:247954 )

• olfactory sensory neuron layer is thinner than control

decreased olfactory sensory neuron number ( J:247954 )

• number of OMP-positive olfactory neurons is decreased in epithelium, however, number of Olfr1507-positive neurons is not reduced

growth/size/body

abnormal olfactory sensory neuron morphology ( J:247954 )

• olfactory sensory neuron layer is thinner than control

decreased olfactory sensory neuron number ( J:247954 )

• number of OMP-positive olfactory neurons is decreased in epithelium, however, number of Olfr1507-positive neurons is not reduced

cellular

increased neuron apoptosis ( J:247954 )

• olfactory sensory neurons exhibit a 5 fold increase in cell death

nervous system

increased neuron apoptosis ( J:247954 )

• olfactory sensory neurons exhibit a 5 fold increase in cell death

abnormal olfactory sensory neuron morphology ( J:247954 )

• olfactory sensory neuron layer is thinner than control

decreased olfactory sensory neuron number ( J:247954 )

• number of OMP-positive olfactory neurons is decreased in epithelium, however, number of Olfr1507-positive neurons is not reduced

abnormal olfactory bulb glomerular layer morphology ( J:247954 )

• number of glomeruli is reduced and average size of glomeruli is smaller than control

small olfactory bulb ( J:247954 )

abnormal olfactory sensory neuron physiology ( J:247954 )

• olfactory neurons in vitro are unresponsive to an odorant mix

respiratory system

abnormal olfactory sensory neuron morphology ( J:247954 )

• olfactory sensory neuron layer is thinner than control

decreased olfactory sensory neuron number ( J:247954 )

• number of OMP-positive olfactory neurons is decreased in epithelium, however, number of Olfr1507-positive neurons is not reduced

abnormal olfactory epithelium physiology ( J:247954 )

• cell death is 5X higher in olfactory epithelium than in controls

abnormal olfactory sensory neuron physiology ( J:247954 )

• olfactory neurons in vitro are unresponsive to an odorant mix

behavior/neurological

behavior/neurological phenotype ( J:247954 )

N • mice do not exhibit anxiety, depression or mobility deficits