Phenotypes associated with this allele

• Allele Symbol: App^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5692874
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	App^tm1b(KOMP)Wtsi/App^tm1b(KOMP)Wtsi	C57BL/6N-App^tm1b(KOMP)Wtsi/Ics	MGI:5797366
ht2	App^tm1b(KOMP)Wtsi/App^+	C57BL/6N-App^tm1b(KOMP)Wtsi/Ics	MGI:5756718

Genotype
MGI:5797366

hm1

• Allelic Composition: App^{tm1b(KOMP)Wtsi}/App^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-App^{tm1b(KOMP)Wtsi}/Ics
• Cell Lines: EPD0797_6_F12

Data Sources

IMPC Data for App

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - ICS

Genotype
MGI:5756718

ht2

• Allelic Composition: App^{tm1b(KOMP)Wtsi}/App⁺
• Genetic Background: C57BL/6N-App^{tm1b(KOMP)Wtsi}/Ics
• Cell Lines: EPD0797_6_F12

Data Sources

IMPC Data for App

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - ICS

hematopoietic system

increased neutrophil cell number ( J:211773 )

♀

IMPC - ICS

increased monocyte cell number ( J:211773 )

♀

IMPC - ICS

homeostasis/metabolism

increased blood urea nitrogen level ( J:211773 )

♂

IMPC - ICS

increased circulating calcium level ( J:211773 )

IMPC - ICS

immune system

increased neutrophil cell number ( J:211773 )

♀

IMPC - ICS

increased monocyte cell number ( J:211773 )

♀

IMPC - ICS

limbs/digits/tail

short tibia ( J:211773 )

IMPC - ICS

skeleton

short tibia ( J:211773 )

IMPC - ICS

vision/eye

increased cornea thickness ( J:211773 )

♂

IMPC - ICS

decreased total retina thickness ( J:211773 )

♀

IMPC - ICS