Phenotypes associated with this allele

• Allele Symbol: Nedd4^{tm2b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 2b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5692904
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nedd4^tm2b(EUCOMM)Hmgu/Nedd4^tm2b(EUCOMM)Hmgu	C57BL/6N-Nedd4^tm2b(EUCOMM)Hmgu/H	MGI:6262998
ht2	Nedd4^tm2b(EUCOMM)Hmgu/Nedd4^+	C57BL/6N-Nedd4^tm2b(EUCOMM)Hmgu/H	MGI:6262997

Genotype
MGI:6262998

hm1

• Allelic Composition: Nedd4^{tm2b(EUCOMM)Hmgu}/Nedd4^{tm2b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Nedd4^{tm2b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0814_3_B10

Data Sources

IMPC Data for Nedd4

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:6262997

ht2

• Allelic Composition: Nedd4^{tm2b(EUCOMM)Hmgu}/Nedd4⁺
• Genetic Background: C57BL/6N-Nedd4^{tm2b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0814_3_B10

Data Sources

IMPC Data for Nedd4

behavior/neurological

abnormal behavior ( J:211773 )

♂

IMPC - HAR

decreased thigmotaxis ( J:211773 )

♂

IMPC - HAR

tremors ( J:211773 )

IMPC - HAR

increased grip strength ( J:211773 )

♀

IMPC - HAR

abnormal gait ( J:211773 )

IMPC - HAR

decreased locomotor activity ( J:211773 )

♂

IMPC - HAR

hematopoietic system

increased leukocyte cell number ( J:211773 )

IMPC - HAR

increased lymphocyte cell number ( J:211773 )

IMPC - HAR

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

♀

IMPC - HAR

impaired glucose tolerance ( J:211773 )

♂

IMPC - HAR

immune system

increased leukocyte cell number ( J:211773 )

IMPC - HAR

increased lymphocyte cell number ( J:211773 )

IMPC - HAR