Phenotypes associated with this allele

• Allele Symbol: Pax5^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5692910
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax5^tm1b(EUCOMM)Wtsi/Pax5^tm1b(EUCOMM)Wtsi	C57BL/6N-Pax5^tm1b(EUCOMM)Wtsi/Ieg	MGI:6263104
ht2	Pax5^tm1b(EUCOMM)Wtsi/Pax5^+	C57BL/6N-Pax5^tm1b(EUCOMM)Wtsi/Ieg	MGI:6263103

Genotype
MGI:6263104

hm1

• Allelic Composition: Pax5^{tm1b(EUCOMM)Wtsi}/Pax5^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Pax5^{tm1b(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0237_3_F11

Data Sources

IMPC Data for Pax5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:6263103

ht2

• Allelic Composition: Pax5^{tm1b(EUCOMM)Wtsi}/Pax5⁺
• Genetic Background: C57BL/6N-Pax5^{tm1b(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0237_3_F11

Data Sources

IMPC Data for Pax5

behavior/neurological

hyperactivity ( J:211773 )

IMPC - HMGU

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - HMGU

hematopoietic system

increased CD4-positive NK T cell number ( J:211773 )

♀

IMPC - HMGU

increased memory-marker CD4-positive NK T cell number ( J:211773 )

♀

IMPC - HMGU

decreased leukocyte cell number ( J:211773 )

♂

IMPC - HMGU

homeostasis/metabolism

increased circulating triglyceride level ( J:211773 )

♂

IMPC - HMGU

increased circulating amylase level ( J:211773 )

♂

IMPC - HMGU

increased circulating lipase level ( J:211773 )

♂

IMPC - HMGU

impaired glucose tolerance ( J:211773 )

IMPC - HMGU

immune system

immune system phenotype ( J:211773 )

♀

IMPC - HMGU

increased CD4-positive NK T cell number ( J:211773 )

♀

IMPC - HMGU

increased memory-marker CD4-positive NK T cell number ( J:211773 )

♀

IMPC - HMGU

decreased leukocyte cell number ( J:211773 )

♂

IMPC - HMGU