Phenotypes associated with this allele

• Allele Symbol: Mybpc3^DBA/2J
• Allele Name: DBA/2J
• Allele ID: MGI:5693397
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mybpc3^DBA/2J/Mybpc3^DBA/2J Myh7^DBA/2J/Myh7^DBA/2J	DBA/2J	MGI:5693406

Genotype
MGI:5693406

cx1

• Allelic Composition: Mybpc3^DBA/2J/Mybpc3^DBA/2J; Myh7^DBA/2J/Myh7^DBA/2J
• Genetic Background: DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:225492 )

N • mice exhibit normal blood pressure and ejection fraction and no signs of myocardial infarction

increased myocardial fiber size ( J:225492 )

• compared with C57BL/6 mice

increased heart weight ( J:225492 )

• compared with C57BL/6 mice

cardiac hypertrophy ( J:225492 )

• mice exhibit increased expression of cardiac hypertropic markers compared with C57BL/6 mice

increased heart left ventricle wall thickness ( J:225492 )

• thick ventricular wall in the left ventricle compared with C57BL/6 mice

cardiac interstitial fibrosis ( J:225492 )

• with numerous myofibroblasts in the interstitial space compared with C57BL/6 mice

abnormal heart echocardiography feature ( J:225492 )

• increased left ventricular diastolic posterior wall thickness and left ventricular systolic posterior wall thickness compared with C57BL/6 mice

• decreased left ventricular diastolic diameter and left ventricle systolic diameter compared with C57BL/6 mice

• however, mice exhibit normal left ventricular diastolic anterior wall thickness and left ventricular systolic anterior wall thickness

growth/size/body

increased heart weight ( J:225492 )

• compared with C57BL/6 mice

cardiac hypertrophy ( J:225492 )

• mice exhibit increased expression of cardiac hypertropic markers compared with C57BL/6 mice

muscle

increased myocardial fiber size ( J:225492 )

• compared with C57BL/6 mice

cellular

cardiac interstitial fibrosis ( J:225492 )

• with numerous myofibroblasts in the interstitial space compared with C57BL/6 mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypertrophic cardiomyopathy		DOID:11984		J:225492