Analysis Tools
behavior/neurological
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• mice exhibit an increased number of continued (perseverative) responses to stimulus in the 5-Choice Serial Reaction Time Task, a measure of compulsive behavior
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• slower learning in stimulus-response (conditional associative learning-CAL), although mice attain same performance level after training
• mice exhibit slower learning to reach training criterion in assay for selective attention (5-Choice Serial Reaction Time Task - 5CSRTT), however once training is complete mice perform as well as controls
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• mice exhibit a deficit in nonspatial working memory in test of increasing delay length between offset of auditory cue and availability of response lever
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• mice exhibit an increased number of premature responses prior to stimulus in the 5-Choice Serial Reaction Time Task, a measure of impulsive behavior
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nervous system
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• increase in dopamine release capacity in the dorsomedial striatum following stimulation of the medial forebrain bundle in comparison to controls
• higher average peak dopamine current
• increased total release volume
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