Phenotypes associated with this allele

• Allele Symbol: Ednra^{tm7(Hand2)Hku}
• Allele Name: targeted mutation 7, Hiroki Kurihara
• Allele ID: MGI:5693853
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ednra^tm7(Hand2)Hku/Ednra^+	chimera involves: 129 * C57BL/6 * ICR	MGI:5694440

Genotype
MGI:5694440

ht1

• Allelic Composition: Ednra^{tm7(Hand2)Hku}/Ednra⁺
• Genetic Background: chimera involves: 129 * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Skeletal abnormalities of Ednra^{tm7(Hand2)Hku}/Ednra⁺ ES cell-derived chimeras at E16.5

mortality/aging

perinatal lethality, complete penetrance ( J:224515 )

• chimeras do not survive after birth

craniofacial

abnormal Meckel's cartilage morphology ( J:224515 )

• Meckel's cartillage-like structure often in the maxillary region but often associated with the ala temporalis

abnormal temporal bone squamous part morphology ( J:224515 )

• often malformed or absent

absent temporal bone squamous part ( J:224515 )

• often absent

upper jaw to lower jaw transformation ( J:224515 )

• maxillary structures transformed into dentary-like bone fused to premaxillary

• incisor at the distal end of the dentary

abnormal gonial bone morphology ( J:224515 )

• often malformed or absent along with ectotympanic bone

absent gonial bone ( J:224515 )

• often absent along with ectotympanic bone

skeleton

abnormal Meckel's cartilage morphology ( J:224515 )

• Meckel's cartillage-like structure often in the maxillary region but often associated with the ala temporalis

abnormal temporal bone squamous part morphology ( J:224515 )

• often malformed or absent

absent temporal bone squamous part ( J:224515 )

• often absent

upper jaw to lower jaw transformation ( J:224515 )

• maxillary structures transformed into dentary-like bone fused to premaxillary

• incisor at the distal end of the dentary

abnormal gonial bone morphology ( J:224515 )

• often malformed or absent along with ectotympanic bone

absent gonial bone ( J:224515 )

• often absent along with ectotympanic bone

hearing/vestibular/ear

abnormal gonial bone morphology ( J:224515 )

• often malformed or absent along with ectotympanic bone

absent gonial bone ( J:224515 )

• often absent along with ectotympanic bone