Analysis Tools
craniofacial
 |
• Background Sensitivity: in females there is a trend toward shortened skull length, smaller skull length to width ratio, and larger skull height to length ratio, which do not reach statistical significance, and in males these measurements reache statistical significance
|
|
• Background Sensitivity: in some mutants misalignment of the jaws leads to malocclusion, which may require tooth trimming
|
malocclusion
(
J:223062
)
|
|
• Background Sensitivity: in females there is a trend toward decreased upper jaw length, which does not reach statistical significance, and in males this measurement reaches statistical significance
|
|
• Background Sensitivity: heterozygotes have a round skull, short nose, and wide-set eyes
|
short face
(
J:223062
)
|
• heterozygotes have a short, blunt face
|
vision/eye
|
|
• Background Sensitivity: in females there is a trend toward increased inner canthal distance, which does not reach statistical significance, and in males this measurement reaches statistical significance
|
hearing/vestibular/ear
|
• ABR testing of one mutant each at 6, 7, and 8 weeks of age found severely impaired hearing or deafness at low frequencies, and click-box testing at 8 weeks of age scored a two on the SHIRPA startle test
|
|
• 3 of 9 heterozygotes between 12 and 24 weeks of age were found to have otitis media and one additional mutant had an abnormally developed inner ear with the incus or malleus still embedded in connective tissue
|
immune system
|
• 3 of 9 heterozygotes between 12 and 24 weeks of age were found to have otitis media and one additional mutant had an abnormally developed inner ear with the incus or malleus still embedded in connective tissue
|
growth/size/body
malocclusion
(
J:223062
)
short face
(
J:223062
)
|
• heterozygotes have a short, blunt face
|
reproductive system
skeleton
|
|
• Background Sensitivity: in females there is a trend toward shortened skull length, smaller skull length to width ratio, and larger skull height to length ratio, which do not reach statistical significance, and in males these measurements reache statistical significance
|
|
• Background Sensitivity: in some mutants misalignment of the jaws leads to malocclusion, which may require tooth trimming
|
malocclusion
(
J:223062
)
|
|
• Background Sensitivity: in females there is a trend toward decreased upper jaw length, which does not reach statistical significance, and in males this measurement reaches statistical significance
|
|
• Background Sensitivity: heterozygotes have a round skull, short nose, and wide-set eyes
|
|
• assessment of 12 week old heterozygotes finds statistically significant increase in the ratio of skull to body areal bone mineral density in males, and a trend that did not reach statistical significance in females
|
