About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cimap2Retro
Retro
MGI:5694208
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cimap2Retro/Cimap2Retro involves: C57BL/6J MGI:5694603
ht2
 		Cimap2Retro/Cimap2+ involves: C57BL/6J MGI:5694624


Genotype
MGI:5694603
hm1
Allelic
Composition		 Cimap2Retro/Cimap2Retro
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cimap2Retro mutation (1 available); any Cimap2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased T cell proliferation ( J:223336 )
• increased proliferation of np396+ CD8+ T cells after LCMV C13 infection as compared to wild type

immune system
increased T cell proliferation ( J:223336 )
• increased proliferation of np396+ CD8+ T cells after LCMV C13 infection as compared to wild type
increased CD8-positive, alpha-beta T cell number ( J:223336 )
• 10 fold increase in the number of LCMV-specific np396+ CD8+ T cells following infection with LCMV clone 13 (C13) as compared to controls
increased central memory CD8 positive, alpha-beta T cell number ( J:223336 )
• 4 fold increase in number of LCMV Armstrong-specific central memory T CD8+ cells in spleen 70 days after infection
increased activated T cell number ( J:223336 )
• increase in CD44hi CD4+ and CD8+ T cells following LCMV C13 infection
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:223336 )
• 10 fold increase in secondary cytotoxic T lymphocytes following second dose of LCMV Armstrong as compared to wild type
increased cytotoxic T cell cytolysis ( J:223336 )
• increased specific CTL lysis as compared to wild type following infection with LCMV clone 13
increased interferon-gamma secretion ( J:223336 )
• increased production of interferon gamma following LCMV C13 infection
increased susceptibility to Riboviria infection induced morbidity/mortality ( J:223336 )
• mice die from LCMV C13 infection after 14 days; wild-type mice survive

hematopoietic system
increased T cell proliferation ( J:223336 )
• increased proliferation of np396+ CD8+ T cells after LCMV C13 infection as compared to wild type
increased CD8-positive, alpha-beta T cell number ( J:223336 )
• 10 fold increase in the number of LCMV-specific np396+ CD8+ T cells following infection with LCMV clone 13 (C13) as compared to controls
increased central memory CD8 positive, alpha-beta T cell number ( J:223336 )
• 4 fold increase in number of LCMV Armstrong-specific central memory T CD8+ cells in spleen 70 days after infection
increased activated T cell number ( J:223336 )
• increase in CD44hi CD4+ and CD8+ T cells following LCMV C13 infection
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:223336 )
• 10 fold increase in secondary cytotoxic T lymphocytes following second dose of LCMV Armstrong as compared to wild type
increased cytotoxic T cell cytolysis ( J:223336 )
• increased specific CTL lysis as compared to wild type following infection with LCMV clone 13

mortality/aging
increased susceptibility to Riboviria infection induced morbidity/mortality ( J:223336 )
• mice die from LCMV C13 infection after 14 days; wild-type mice survive

neoplasm
decreased lung tumor incidence ( J:223336 )
• decreased number of lung tumors following challenge with B16 F10 melanoma cells as compared to wild type

respiratory system
decreased lung tumor incidence ( J:223336 )
• decreased number of lung tumors following challenge with B16 F10 melanoma cells as compared to wild type




Genotype
MGI:5694624
ht2
Allelic
Composition		 Cimap2Retro/Cimap2+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cimap2Retro mutation (1 available); any Cimap2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased CD8-positive, alpha-beta T cell number ( J:223336 )
• increase in the number of LCMV-specific np396+ CD8+ T cells following infection with LCMV clone 13 (C13) as compared to controls
• increase in cell numbers is less than in homozygote
increased cytotoxic T cell cytolysis ( J:223336 )
• increased specific CTL lysis as compared to wild type
• increase in cytolysis is less than in homozygote

immune system
increased CD8-positive, alpha-beta T cell number ( J:223336 )
• increase in the number of LCMV-specific np396+ CD8+ T cells following infection with LCMV clone 13 (C13) as compared to controls
• increase in cell numbers is less than in homozygote
increased cytotoxic T cell cytolysis ( J:223336 )
• increased specific CTL lysis as compared to wild type
• increase in cytolysis is less than in homozygote




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory