Phenotypes associated with this allele

• Allele Symbol: Pak1^tm1Zpj
• Allele Name: targeted mutation 1, Zhengping Jia
• Allele ID: MGI:5694233
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pak1^tm1Zpj/Pak1^tm1Zpj	involves: 129S1/Sv * 129X1/SvJ	MGI:5694245

Genotype
MGI:5694245

hm1

• Allelic Composition: Pak1^tm1Zpj/Pak1^tm1Zpj
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:225714 )

N • mice exhibit normal basal synaptic strength and presynaptic function, current-voltage relation in either excitatory postsynaptic currents mediated by NMDA or AMPA receptors, synaptic and spine structures

reduced long-term potentiation ( J:225714 )

• however, long term depression induced by metabotropic glutamate receptor agonist (RS)-3,5-DHPG or by low frequency stimulation (1 Hz lasting 15 min)