Phenotypes associated with this allele

• Allele Symbol: Afap1l2^tm1.1Mliu
• Allele Name: targeted mutation 1.1, Mingyao Liu
• Allele ID: MGI:5694611
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Afap1l2^tm1.1Mliu/Afap1l2^tm1.1Mliu	B6.129P2(Cg)-Afap1l2^tm1.1Mliu	MGI:6382178

Genotype
MGI:6382178

hm1

• Allelic Composition: Afap1l2^tm1.1Mliu/Afap1l2^tm1.1Mliu
• Genetic Background: B6.129P2(Cg)-Afap1l2^tm1.1Mliu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal tracheal ciliated epithelium morphology ( J:223478 )

• the tracheal epithelium is thicker

• however, no difference in cell density is seen in the tracheal epithelium

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:223478 )

N • mice appear normal at birth and show normal life span, show normal results in skeletal X-ray, body composition, ECG, hematology, blood biochemistry, urinalysis, and glucose tolerance test

abnormal response to injury ( J:223478 )

• mice exhibit a transient tracheal epithelial hyperplasia during airway repair after injury (isogenic tracheal subcutaneous transplantation), showing a thicker epithelium associated with greater proliferative and basal cells, as well as thickening of the connective tissue and fibroblast layer between the epithelium and tracheal cartilage at day 10 after transplantation

• however, repair of tracheal transplant-related epithelial injury is similar to wild-type mice, with mice showing similar severity of epithelial injury, apoptosis, and cell spreading as in wild-type mice