All Phenotypes Rec8<tm1b(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rec8^{tm1b(KOMP)Wtsi}
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:5694668

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi}	B6N(Cg)-Rec8^{tm1b(KOMP)Wtsi}	MGI:6506386
hm2	Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi}	C57BL/6N-Rec8^{tm1b(KOMP)Wtsi}/J	MGI:6263351
cx3	Prdm9^tm1Ymat/Prdm9^tm1Ymat Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi}	B6.Cg-Prdm9^tm1Ymat Rec8^{tm1b(KOMP)Wtsi}	MGI:6506408
cx4	Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi} Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi}	B6N(Cg)-Rad21l^{tm1b(KOMP)Wtsi} Rec8^{tm1b(KOMP)Wtsi}	MGI:6506394
cx5	Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}	B6N(Cg)-Rec8^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}	MGI:6506390

Allelic Composition	Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi}
Genetic Background	B6N(Cg)-Rec8^{tm1b(KOMP)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rec8^{tm1b(KOMP)Wtsi} mutation (1 available); any Rec8 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male meiosis ( J:280261 )

• reduced number (80% of WT) of recombination hotspots in leptotene-like spermatocytes

cellular

abnormal male meiosis ( J:280261 )

• reduced number (80% of WT) of recombination hotspots in leptotene-like spermatocytes

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (77% of WT) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (77% of WT) in spermatocytes

Allelic Composition	Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Rec8^{tm1b(KOMP)Wtsi}/J
Cell Lines	EPD0208_2_A04

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rec8^{tm1b(KOMP)Wtsi} mutation (1 available); any Rec8 mutation (25 available)

Data Sources

IMPC Data for Rec8

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - JAX

hematopoietic system

increased mean corpuscular hemoglobin concentration ( J:211773 )

IMPC - JAX

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

IMPC - JAX

increased circulating HDL cholesterol level ( J:211773 )

IMPC - JAX

increased circulating aspartate transaminase level ( J:211773 )

IMPC - JAX

reproductive system

male infertility ( J:211773 )

IMPC - JAX

Allelic Composition	Prdm9^tm1Ymat/Prdm9^tm1Ymat Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi}
Genetic Background	B6.Cg-Prdm9^tm1Ymat Rec8^{tm1b(KOMP)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm9^tm1Ymat mutation (3 available); any Prdm9 mutation (46 available)
Rec8^{tm1b(KOMP)Wtsi} mutation (1 available); any Rec8 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (60-80% of WT or single KO) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (60-80% of WT or single KO) in spermatocytes

Allelic Composition	Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi} Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi}
Genetic Background	B6N(Cg)-Rad21l^{tm1b(KOMP)Wtsi} Rec8^{tm1b(KOMP)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21l^{tm1b(KOMP)Wtsi} mutation (1 available); any Rad21l mutation (34 available)
Rec8^{tm1b(KOMP)Wtsi} mutation (1 available); any Rec8 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (20-30% of WT or single KO) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (20-30% of WT or single KO) in spermatocytes

Allelic Composition	Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}
Genetic Background	B6N(Cg)-Rec8^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rec8^{tm1b(KOMP)Wtsi} mutation (1 available); any Rec8 mutation (25 available)
Stag3^{tm1e.1(KOMP)Wtsi} mutation (1 available); any Stag3 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male meiosis ( J:280261 )

• reduced number (25% of WT, 42-61% of either single KO) of recombination hotspots in leptotene-like spermatocytes

abnormal synaptonemal complex ( J:280261 )

• absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

cellular

abnormal male meiosis ( J:280261 )

• reduced number (25% of WT, 42-61% of either single KO) of recombination hotspots in leptotene-like spermatocytes

abnormal synaptonemal complex ( J:280261 )

• absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (40% of either single KO or 60% of WT) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (40% of either single KO or 60% of WT) in spermatocytes

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