Phenotypes associated with this allele

• Allele Symbol: Vcan^tm2Hwat
• Allele Name: targeted mutation 2, Hideto Watanabe
• Allele ID: MGI:5694701
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vcan^tm2Hwat/Vcan^tm2Hwat	B6.Cg-Vcan^tm2Hwat	MGI:5694707
hm2	Vcan^tm2Hwat/Vcan^tm2Hwat	involves: 129 * BALB/c * C57BL/6	MGI:5694708
hm3	Vcan^tm2Hwat/Vcan^tm2Hwat	involves: 129 * C57BL/6	MGI:5694709

Genotype
MGI:5694707

hm1

• Allelic Composition: Vcan^tm2Hwat/Vcan^tm2Hwat
• Genetic Background: B6.Cg-Vcan^tm2Hwat

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:225115 )

• all mice die at E10.5

Genotype
MGI:5694708

hm2

• Allelic Composition: Vcan^tm2Hwat/Vcan^tm2Hwat
• Genetic Background: involves: 129 * BALB/c * C57BL/6

mortality/aging

neonatal lethality, complete penetrance ( J:225115 )

• all mice that are born die within 6 hours of birth

embryonic lethality during organogenesis, incomplete penetrance ( J:225115 )

• most mice die by E10.5

cardiovascular system

decreased atrioventricular cushion size ( J:225115 )

• reduced volume

abnormal interventricular septum morphology ( J:225115 )

• interventricular septa about to fuse to the top of cardiac wall at E14.5

• nearly fused at P0

ventricular septal defect ( J:225115 )

• at E14.5 and P0

abnormal cardiovascular system physiology ( J:225115 )

• endocardial cell proliferation is increased at E12.5 compared with wild-type cells

• mesenchymal cells exhibit impaired cell migration compared with wild-type cells

growth/size/body

decreased fetal size ( J:225115 )

• surviving mice at E14.5

homeostasis/metabolism

cyanosis ( J:225115 )

• at birth

Genotype
MGI:5694709

hm3

• Allelic Composition: Vcan^tm2Hwat/Vcan^tm2Hwat
• Genetic Background: involves: 129 * C57BL/6

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:225115 )

• mice die by E13.5