Phenotypes associated with this allele

• Allele Symbol: Wdr13^tm1Kuma
• Allele Name: targeted mutation 1, Satish Kumar
• Allele ID: MGI:5694710
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wdr13^tm1Kuma/Wdr13^tm1Kuma	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:5694718
ot2	Wdr13^tm1Kuma/Y	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:5694719

Genotype
MGI:5694718

hm1

• Allelic Composition: Wdr13^tm1Kuma/Wdr13^tm1Kuma
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:225111 )

♀N • mice are fertile

growth/size/body

increased pancreas weight ( J:225111 )

♀ • at 11 months

increased body weight ( J:225111 )

♀ • at 11 months

adipose tissue

increased white fat cell size ( J:225111 )

♀ • in the skin

increased gonadal fat pad weight ( J:225111 )

♀ • 2-fold increase in the ovarian fat pad

endocrine/exocrine glands

increased pancreas weight ( J:225111 )

♀ • at 11 months

Genotype
MGI:5694719

ot2

• Allelic Composition: Wdr13^tm1Kuma/Y
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

reproductive system

reproductive system phenotype ( J:225111 )

♂N • mice are fertile and produce normal litter sizes

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:225111 )

♂N • mice fed standard chow or a high fat diet exhibit unaltered insulin sensitivity and insulin secretion

increased susceptibility to diet-induced obesity ( J:225111 )

♂ • in mice fed a high fat diet at 5 months

decreased circulating glucose level ( J:225111 )

♂ • in mice fed standard chow decreased random fed glucose serum levels at 12, but not 2 months, compared with wild-type mice

♂ • however, fasting glucose serum levels are normal at 2 and 12 months

increased circulating insulin level ( J:225111 )

♂ • mice fed standard chow exhibit decreased random fed insulin serum levels at 12, but not 2 months, compared with wild-type mice

♂ • in mice fed a high fat diet, fed insulin serum levels are increased at 6 months compared with wild-type mice

♂ • however, fasting insulin serum levels are normal at 2 and 12 months

improved glucose tolerance ( J:225111 )

♂ • marginally increased glucose clearance at 12 months in mice fed standard chow

♂ • increased glucose clearance at 6 months in mice fed a high fat diet

endocrine/exocrine glands

increased pancreatic beta cell proliferation ( J:225111 )

♂ • 2-fold in mice fed a high fat diet

pancreatic islet hyperplasia ( J:225111 )

♂ • increased islet mass in mice fed a high fat diet at 6 months

increased pancreas weight ( J:225111 )

♂ • at 12 month

adipose tissue

increased white fat cell size ( J:225111 )

♂ • in the epididymal fat pad and skin

increased epididymal fat pad weight ( J:225111 )

♂ • 2.5-fold

growth/size/body

increased pancreas weight ( J:225111 )

♂ • at 12 month

increased body weight ( J:225111 )

♂ • in mice fed standard chow at 11 months

♂ • in 5 month old mice fed a high fat diet starting at 1 month

increased susceptibility to diet-induced obesity ( J:225111 )

♂ • in mice fed a high fat diet at 5 months

cellular

increased pancreatic beta cell proliferation ( J:225111 )

♂ • 2-fold in mice fed a high fat diet

behavior/neurological

behavior/neurological phenotype ( J:225111 )

♂N • mice exhibit normal food consumption