Phenotypes associated with this allele

• Allele Symbol: Kcnmb2^tm1.2Clin
• Allele Name: targeted mutation 1.2, Christopher J Lingle
• Allele ID: MGI:5694812
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnmb2^tm1.2Clin/Kcnmb2^tm1.2Clin	B6(FVB)-Kcnmb2^tm1.2Clin	MGI:5695222

Genotype
MGI:5695222

hm1

• Allelic Composition: Kcnmb2^tm1.2Clin/Kcnmb2^tm1.2Clin
• Genetic Background: B6(FVB)-Kcnmb2^tm1.2Clin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal action potential ( J:225860 )

• action potential (AP) depolarization is slowed during AP falling phase and times as compared to wild-type

• peak amplitude of evoked action potentials is reduced as compared to wild-type

• peak dV/dT measured in spontaneous action potentials is lower as compared to wild type

impaired ability to fire action potentials ( J:225860 )

• 80% of chromaffin cells exhibit spontaneous firing as a brief burst of a single full AP followed by a lower-amplitude AP in contrast to very little burst firing in wild-type

• decreased action potential firing during constant current injection

• smaller, sustained current injection in chromaffin cells results in weaker firing in response to stronger levels of current as compared to wild type

abnormal channel response ( J:225860 )

• activated BK current peak in chromaffin cells exceeds wild-type

• chromaffin cells from adrenal medullary slices do not exhibit inactivating Big Potassium (BK) channel currents in contrast to wild-type cells

• loading steps in chromaffin cells activate a non-inactivating outward current