Phenotypes associated with this allele

• Allele Symbol: Spns2^tm1Tni
• Allele Name: targeted mutation 1, Tsuyoshi Nishi
• Allele ID: MGI:5694845
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spns2^tm1Tni/Spns2^tm1Tni	B6.Cg-Spns2^tm1Tni	MGI:5695497

Genotype
MGI:5695497

hm1

• Allelic Composition: Spns2^tm1Tni/Spns2^tm1Tni
• Genetic Background: B6.Cg-Spns2^tm1Tni

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Spns2^tm1Tni/Spns2^tm1Tni mice show an eye-open at birth phenotype

mortality/aging

decreased survivor rate ( J:225108 )

• 40% die of unknown causes at 4-5 weeks of age

growth/size/body

growth/size/body region phenotype ( J:225108 )

N • no obvious cardiovascular or other organ abnormalities observed

decreased body weight ( J:225108 )

• body weight is significantly reduced at 4 weeks of age but not in heterozygotes

vision/eye

eyelids open at birth ( J:225108 )

• born at expected Mendelian ratios but with eyes open

homeostasis/metabolism

decreased sphingosine level ( J:225108 )

• serum levels of Sphingosine-1-phosphate about 60% of control levels

• organ and whole blood levels are normal

• aortic endothelial cell release of Sphingosine-1-phosphate fails

• erythrocyte and platelet release of Sphingosine-1-phosphate is unaffected

hematopoietic system

abnormal thymus morphology ( J:225108 )

• increased numbers of mature T cells in the thymus

• mature T cells show greater migration activity

abnormal leukocyte cell number ( J:225108 )

abnormal mature B cell number ( J:225108 )

• B220+ B cell number is reduced in half

decreased leukocyte cell number ( J:225108 )

• significantly fewer leukocytes in circulation

• numbers of other formed elements of the blood are normal

decreased lymphocyte cell number ( J:225108 )

• drastic reduction in lymphocyte numbers

decreased thymocyte number ( J:225108 )

• number of immature T cells in the thymus is reduced

decreased single-positive T cell number ( J:225108 )

• significantly reduced in the circulation

decreased monocyte cell number ( J:225108 )

• slightly reduced

immune system

abnormal thymus morphology ( J:225108 )

• increased numbers of mature T cells in the thymus

• mature T cells show greater migration activity

abnormal leukocyte cell number ( J:225108 )

abnormal mature B cell number ( J:225108 )

• B220+ B cell number is reduced in half

decreased leukocyte cell number ( J:225108 )

• significantly fewer leukocytes in circulation

• numbers of other formed elements of the blood are normal

decreased lymphocyte cell number ( J:225108 )

• drastic reduction in lymphocyte numbers

decreased thymocyte number ( J:225108 )

• number of immature T cells in the thymus is reduced

decreased single-positive T cell number ( J:225108 )

• significantly reduced in the circulation

decreased monocyte cell number ( J:225108 )

• slightly reduced

endocrine/exocrine glands

abnormal thymus morphology ( J:225108 )

• increased numbers of mature T cells in the thymus

• mature T cells show greater migration activity

decreased thymocyte number ( J:225108 )

• number of immature T cells in the thymus is reduced