Phenotypes associated with this allele

• Allele Symbol: Npy1r^tm1Snby
• Allele Name: targeted mutation 1, Amanda Sainsbury
• Allele ID: MGI:5694958
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Npy1r^tm1Snby/Npy1r^tm1Snby Npy5r^tm1Snby/Npy5r^tm1Snby	involves: 129 * C57BL/6	MGI:5694992

Genotype
MGI:5694992

cn1

• Allelic Composition: Npy1r^tm1Snby/Npy1r^tm1Snby; Npy5r^tm1Snby/Npy5r^tm1Snby
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:225097 )

N • mice fed normal chow injected with a cre recombinase expressing adenovirus exhibit normal energy expenditure

increased circulating glucose level ( J:225097 )

♀ • after intraperitoneal glucose injection in female, but not male, mice fed a standard chow injected with a cre recombinase expressing adenovirus at 18, but not 35 weeks

♀ • however, no difference was observed in mice fed a high fat diet

increased energy expenditure ( J:225097 )

♂ • in male, but not female mice, fed a high fat diet injected with a cre recombinase expressing adenovirus at 19 and 36 weeks

decreased respiratory quotient ( J:225097 )

♀ • during the light phase in female mice fed a high fat diet injected with a cre recombinase expressing adenovirus at 19 weeks

increased respiratory quotient ( J:225097 )

♀ • in female mice fed a standard chow injected with a cre recombinase expressing adenovirus at 36 weeks

impaired glucose tolerance ( J:225097 )

♂ • after intraperitoneal insulin injection male mice injected with a cre recombinase expressing adenovirus exhibit a blunted drop in serum glucose levels at 18 weeks in mice fed standard chow and 35 weeks in mice fed high fat diet

growth/size/body

growth/size/body region phenotype ( J:225097 )

N • mice injected with a cre recombinase expressing adenovirus exhibit normal lean mass at 19, 27 or 36 weeks

increased body weight ( J:225097 )

• in female and male mice fed a high fat diet injected with a cre recombinase expressing adenovirus

decreased susceptibility to weight gain ( J:225097 )

♂ • delayed body weight recovery during refeeding in male, but not female, mice fed standard chow injected with a cre recombinase expressing adenovirus at 17, but not 34 weeks

behavior/neurological

decreased food intake ( J:225097 )

• in mice fed a high fat diet injected with a cre recombinase expressing adenovirus at 34, but not 17, weeks

decreased compensatory feeding amount ( J:225097 )

• following a fast in mice fed a high fat diet injected with a cre recombinase expressing adenovirus at 34, but not 17, weeks

decreased locomotor activity ( J:225097 )

• in mice fed normal chow injected with a cre recombinase expressing adenovirus at 19 and 36 weeks

hyperactivity ( J:225097 )

• in male mice fed a high fat diet injected with a cre recombinase expressing adenovirus at 19 weeks

• in female mice fed a high fat diet injected with a cre recombinase expressing adenovirus at 36 weeks

adipose tissue

increased white adipose tissue amount ( J:225097 )

♂ • in male mice fed a high fat diet injected with a cre recombinase expressing adenovirus

increased total body fat amount ( J:225097 )

♂ • in male mice fed a high fat diet injected with a cre recombinase expressing adenovirus