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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrc4m1Btlr
mutation 1, Bruce Beutler
MGI:5695007
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrc4m1Btlr/Nlrc4m1Btlr C57BL/6J-Nlrc4m1Btlr MGI:5695050
ht2
 		Nlrc4m1Btlr/Nlrc4+ C57BL/6J-Nlrc4m1Btlr MGI:5695051


Genotype
MGI:5695050
hm1
Allelic
Composition		 Nlrc4m1Btlr/Nlrc4m1Btlr
Genetic
Background		 C57BL/6J-Nlrc4m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4m1Btlr mutation (0 available); any Nlrc4 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:225933 )
• mice exhibit slight impaired peritoneal macrophage inflammatory responses (i.e., decreased secretion of the proinflammatory cytokine interleukin (IL)-1) in response to priming with flagellin compared with wild-type mice




Genotype
MGI:5695051
ht2
Allelic
Composition		 Nlrc4m1Btlr/Nlrc4+
Genetic
Background		 C57BL/6J-Nlrc4m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4m1Btlr mutation (0 available); any Nlrc4 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:225933 )
• mice exhibit impaired peritoneal macrophage inflammatory responses (i.e., decreased secretion of the proinflammatory cytokine interleukin (IL)-1) in response to priming with flagellin compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory