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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mlklm1Btlr
mutation 1, Bruce Beutler
MGI:5695009
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mlklm1Btlr/Mlklm1Btlr C57BL/6J-Mlklm1Btlr MGI:5695047
ht2
Mlklm1Btlr/Mlkl+ C57BL/6J-Mlklm1Btlr MGI:5695048


Genotype
MGI:5695047
hm1
Allelic
Composition
Mlklm1Btlr/Mlklm1Btlr
Genetic
Background
C57BL/6J-Mlklm1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlklm1Btlr mutation (0 available); any Mlkl mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit resistance to lipopolysaccharide (LPS)-induced necroptosis compared with wild-type mice

cellular
• mice exhibit resistance to lipopolysaccharide (LPS)-induced necroptosis compared with wild-type mice




Genotype
MGI:5695048
ht2
Allelic
Composition
Mlklm1Btlr/Mlkl+
Genetic
Background
C57BL/6J-Mlklm1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlklm1Btlr mutation (0 available); any Mlkl mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice slight exhibit resistance to lipopolysaccharide (LPS)-induced necroptosis compared with wild-type mice

cellular
• mice exhibit slight resistance to lipopolysaccharide (LPS)-induced necroptosis compared with wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory