Phenotypes associated with this allele

• Allele Symbol: Tysnd1^tm1.1Arte
• Allele Name: targeted mutation 1.1, TaconicArtemis
• Allele ID: MGI:5695314
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tysnd1^tm1.1Arte/Tysnd1^tm1.1Arte	involves: C57BL/6J * C57BL/6N	MGI:5695334

Genotype
MGI:5695334

hm1

• Allelic Composition: Tysnd1^tm1.1Arte/Tysnd1^tm1.1Arte
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Male Tysnd1^tm1.1Arte/Tysnd1^tm1.1Arte mice are infertile

reproductive system

reproductive system phenotype ( J:223054 )

♀N • female mice produced normal litter sizes

abnormal sperm axoneme morphology ( J:223054 )

♂ • coiled

abnormal sperm mitochondrial sheath morphology ( J:223054 )

♂

abnormal acrosome morphology ( J:223054 )

♂ • abnormal anterior acrosome lacking the acrosomal cap

globozoospermia ( J:223054 )

♂

male infertility ( J:223054 )

♂

decreased fertilization frequency ( J:223054 )

♂ • when the cumulus mass is intact

liver/biliary system

enlarged liver ( J:223054 )

♂ • in phytol in CMC-fed mice

abnormal hepatocyte morphology ( J:223054 )

♂ • enlarged peroxisomes in carboxy methyl cellulose (CMC)-fed mice

♂ • decreased number of peroxisomes and an increase in autophagosomes in the liver in phytol in CMC-fed mice

♂ • however, mitochondria appear intact

hepatic steatosis ( J:223054 )

♂ • phytol-fed males have increased amount of total fat and triglycerides, indicating onset of fatty liver

pale liver ( J:223054 )

♂ • beige in phytol in CMC-fed mice

homeostasis/metabolism

increased circulating alanine transaminase level ( J:223054 )

♂ • in phytol in CMC-fed mice

increased circulating aspartate transaminase level ( J:223054 )

♂ • in phytol in CMC-fed mice

increased circulating lactate dehydrogenase level ( J:223054 )

♂ • in phytol in CMC-fed mice

decreased plasmalogen level ( J:223054 )

♂ • several plasmalogen species are reduced compared to in wild-type mice

♂ • however, total levels are normal

behavior/neurological

decreased locomotor activity ( J:223054 )

♂ • reduced home cage activity in male mice at 34 weeks

cellular

abnormal sperm axoneme morphology ( J:223054 )

♂ • coiled

abnormal sperm mitochondrial sheath morphology ( J:223054 )

♂

abnormal acrosome morphology ( J:223054 )

♂ • abnormal anterior acrosome lacking the acrosomal cap

globozoospermia ( J:223054 )

♂

growth/size/body

enlarged liver ( J:223054 )

♂ • in phytol in CMC-fed mice