Phenotypes associated with this allele

• Allele Symbol: Tnfaip3^tm1.1Gho
• Allele Name: targeted mutation 1.1, Sankar Ghosh
• Allele ID: MGI:5695623
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfaip3^tm1.1Gho/Tnfaip3^tm1.1Gho	involves: C57BL/6J	MGI:5779879

Genotype
MGI:5779879

hm1

• Allelic Composition: Tnfaip3^tm1.1Gho/Tnfaip3^tm1.1Gho
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:217021 )

N • surprisingly, homozygotes exhibit a normal lifespan with no external signs of inflammation, show normal organ histology and normal proportions of B, T, dendritic, and myeloid cells at 6 weeks of age, respond normally to LPS and TNF, and undergo normal NF-kappaB activation

enlarged spleen ( J:217021 )

• splenomegaly at 6 months of age

hematopoietic system

enlarged spleen ( J:217021 )

• splenomegaly at 6 months of age

increased myeloid cell number ( J:217021 )

• increased number of myeloid cells in the bone marrow and spleen at 6 months of age

increased myeloid cell number in bone marrow ( J:217021 )

• as mice age to 6 months

growth/size/body

enlarged spleen ( J:217021 )

• splenomegaly at 6 months of age