All Phenotypes Mki67<em1Dfis> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mki67^em1Dfis
endonuclease-mediated mutation 1, Daniel Fisher
MGI:5695662

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mki67^em1Dfis/Mki67^em1Dfis	involves: C57BL/6J	MGI:6715307
ht2	Mki67^em1Dfis/Mki67⁺	involves: C57BL/6J	MGI:6715306
cx3	Apc^tm1Cip/Apc⁺ Mki67^em1Dfis/Mki67^em1Dfis	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:6715308

Allelic Composition	Mki67^em1Dfis/Mki67^em1Dfis
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mki67^em1Dfis mutation (0 available); any Mki67 mutation (146 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:304800 )

• 16 weeks after AOM-DSS treatment, homozygotes exhibit no macroscopic intestinal neoplastic lesions, unlike similarly treated wild-type and heterozygous mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:304800 )

• 16 weeks after AOM-DSS treatment, homozygotes exhibit no macroscopic intestinal neoplastic lesions, unlike similarly treated wild-type and heterozygous mice

immune system

immune system phenotype ( J:304800 )

• during induction of colon tumors by azoxymethane/dextran sodium sulfate (AOM-DSS) treatment, DSS-treated homozygotes show a similar decrease in body weight and a typical DSS-induced colitis (with increased numbers of immune cells in the lamina propria, moderate crypt cells damage, and hyperplasia) relative to heterozygous controls

Allelic Composition	Mki67^em1Dfis/Mki67⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mki67^em1Dfis mutation (0 available); any Mki67 mutation (146 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor growth/size ( J:304800 )

• 16 weeks after induction of colon tumors by azoxymethane/dextran sodium sulfate (AOM-DSS) treatment, heterozygotes show a significant increase in total lesion area (mm2) but no difference in the total number of lesions/mouse relative to similarly treated wild-type controls

Allelic Composition	Apc^tm1Cip/Apc⁺ Mki67^em1Dfis/Mki67^em1Dfis
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Cip mutation (0 available); any Apc mutation (158 available)
Mki67^em1Dfis mutation (0 available); any Mki67 mutation (146 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:304800 )

• 6 months after induction of colon tumors by AOM-DSS treatment, mice exhibit a significant decrease both in the number of neoplastic lesions/mouse and in total lesion area (mm2) relative to similarly treated mice heterozygous for Mki67^em1Dfis and Apc^tm1Cip

decreased tumor growth/size ( J:304800 )

• 6 months after AOM-DSS treatment, mice exhibit a significant decrease in total lesion area (mm2) relative to similarly treated mice heterozygous for Mki67^em1Dfis and Apc^tm1Cip

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:304800 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24