All Phenotypes Mki67<em1Dfis> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mki67^em1Dfis
endonuclease-mediated mutation 1, Daniel Fisher
MGI:5695662

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mki67^em1Dfis/Mki67^em1Dfis	involves: C57BL/6J	MGI:6715307
ht2	Mki67^em1Dfis/Mki67⁺	involves: C57BL/6J	MGI:6715306
cx3	Apc^tm1Cip/Apc⁺ Mki67^em1Dfis/Mki67^em1Dfis	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:6715308

Allelic Composition	Mki67^em1Dfis/Mki67^em1Dfis
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mki67^em1Dfis mutation (0 available); any Mki67 mutation (146 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:304800 )

• 16 weeks after AOM-DSS treatment, homozygotes exhibit no macroscopic intestinal neoplastic lesions, unlike similarly treated wild-type and heterozygous mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:304800 )

• 16 weeks after AOM-DSS treatment, homozygotes exhibit no macroscopic intestinal neoplastic lesions, unlike similarly treated wild-type and heterozygous mice

immune system

immune system phenotype ( J:304800 )

• during induction of colon tumors by azoxymethane/dextran sodium sulfate (AOM-DSS) treatment, DSS-treated homozygotes show a similar decrease in body weight and a typical DSS-induced colitis (with increased numbers of immune cells in the lamina propria, moderate crypt cells damage, and hyperplasia) relative to heterozygous controls

Allelic Composition	Mki67^em1Dfis/Mki67⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mki67^em1Dfis mutation (0 available); any Mki67 mutation (146 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor growth/size ( J:304800 )

• 16 weeks after induction of colon tumors by azoxymethane/dextran sodium sulfate (AOM-DSS) treatment, heterozygotes show a significant increase in total lesion area (mm2) but no difference in the total number of lesions/mouse relative to similarly treated wild-type controls

Allelic Composition	Apc^tm1Cip/Apc⁺ Mki67^em1Dfis/Mki67^em1Dfis
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Cip mutation (0 available); any Apc mutation (158 available)
Mki67^em1Dfis mutation (0 available); any Mki67 mutation (146 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:304800 )

• 6 months after induction of colon tumors by AOM-DSS treatment, mice exhibit a significant decrease both in the number of neoplastic lesions/mouse and in total lesion area (mm2) relative to similarly treated mice heterozygous for Mki67^em1Dfis and Apc^tm1Cip

decreased tumor growth/size ( J:304800 )

• 6 months after AOM-DSS treatment, mice exhibit a significant decrease in total lesion area (mm2) relative to similarly treated mice heterozygous for Mki67^em1Dfis and Apc^tm1Cip

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:304800 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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