Phenotypes associated with this allele

• Allele Symbol: Ccl27a^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5695899
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccl27a^tm1.1(KOMP)Vlcg/Ccl27a^tm1.1(KOMP)Vlcg	C57BL/6N-Ccl27a^tm1.1(KOMP)Vlcg/MbpMmucd	MGI:7643496
cx2	Ccl27a^tm1.1(KOMP)Vlcg/Ccl27a^tm1.1(KOMP)Vlcg Ccr10^tm1.1Nax/Ccr10^+	B6.Cg-Ccl27a^tm1.1(KOMP)Vlcg Ccr10^tm1.1Nax	MGI:7643504

Genotype
MGI:7643496

hm1

• Allelic Composition: Ccl27a^{tm1.1(KOMP)Vlcg}/Ccl27a^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Ccl27a^{tm1.1(KOMP)Vlcg}/MbpMmucd
• Cell Lines: 14813A-F9

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:330550 )

N • adult mice show no significant differences in the percentages of CD4+, CD8+, or gamma-delta T cells in skin relative to wild-type or heterozygous controls

decreased regulatory T cell number ( J:330550 )

• adult mice show a marginal reduction of Treg cells in skin relative to wild-type or heterozygous controls

hematopoietic system

decreased regulatory T cell number ( J:330550 )

• adult mice show a marginal reduction of Treg cells in skin relative to wild-type or heterozygous controls

Genotype
MGI:7643504

cx2

• Allelic Composition: Ccl27a^{tm1.1(KOMP)Vlcg}/Ccl27a^{tm1.1(KOMP)Vlcg}; Ccr10^tm1.1Nax/Ccr10⁺
• Genetic Background: B6.Cg-Ccl27a^{tm1.1(KOMP)Vlcg} Ccr10^tm1.1Nax
• Cell Lines: 14813A-F9

immune system

immune system phenotype ( J:330550 )

N • adult mice show no significant differences in the percentages of CCR10(EGFP)+ Treg or other T cell subsets (CD4+, CD8+, and gamma-delta T cells) in skin relative to controls, indicating normal establishment of CCR10+ lymphocytes in adult skin