Phenotypes associated with this allele

• Allele Symbol: Exosc3^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5695911
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Exosc3^tm1.1(KOMP)Vlcg/Exosc3^tm1.1(KOMP)Vlcg	C57BL/6N-Exosc3^tm1.1(KOMP)Vlcg/Ucd	MGI:5706002
ht2	Exosc3^tm1.1(KOMP)Vlcg/Exosc3^+	C57BL/6N-Exosc3^tm1.1(KOMP)Vlcg/Ucd	MGI:5797521

Genotype
MGI:5706002

hm1

• Allelic Composition: Exosc3^{tm1.1(KOMP)Vlcg}/Exosc3^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Exosc3^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 10322B-F12

Data Sources

IMPC Data for Exosc3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - UCD

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - UCD

preweaning lethality, complete penetrance ( J:211773 )

♀

IMPC - UCD

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:5797521

ht2

• Allelic Composition: Exosc3^{tm1.1(KOMP)Vlcg}/Exosc3⁺
• Genetic Background: C57BL/6N-Exosc3^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 10322B-F12

Data Sources

IMPC Data for Exosc3

cardiovascular system

abnormal heart morphology ( J:211773 )

IMPC - UCD

enlarged heart ( J:211773 )

IMPC - UCD

growth/size/body

enlarged heart ( J:211773 )

IMPC - UCD

polycystic kidney ( J:211773 )

♂

IMPC - UCD

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

♀

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

♂

IMPC - UCD

polycystic kidney ( J:211773 )

♂

IMPC - UCD