Phenotypes associated with this allele

• Allele Symbol: Cox15^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5695926
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cox15^tm1.1(KOMP)Vlcg/Cox15^tm1.1(KOMP)Vlcg	C57BL/6N-Cox15^tm1.1(KOMP)Vlcg/MbpMmucd	MGI:6325127
hm2	Cox15^tm1.1(KOMP)Vlcg/Cox15^tm1.1(KOMP)Vlcg	C57BL/6N-Cox15^tm1.1(KOMP)Vlcg/Ucd	MGI:5767611
ht3	Cox15^tm1.1(KOMP)Vlcg/Cox15^+	C57BL/6N-Cox15^tm1.1(KOMP)Vlcg/Ucd	MGI:5797444

Genotype
MGI:6325127

hm1

• Allelic Composition: Cox15^{tm1.1(KOMP)Vlcg}/Cox15^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Cox15^{tm1.1(KOMP)Vlcg}/MbpMmucd
• Cell Lines: 15926A-D3

Data Sources

IMPC Data for Cox15

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - TCP

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

Genotype
MGI:5767611

hm2

• Allelic Composition: Cox15^{tm1.1(KOMP)Vlcg}/Cox15^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Cox15^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 15926A-D3

Data Sources

IMPC Data for Cox15

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:5797444

ht3

• Allelic Composition: Cox15^{tm1.1(KOMP)Vlcg}/Cox15⁺
• Genetic Background: C57BL/6N-Cox15^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 15926A-D3

Data Sources

IMPC Data for Cox15

cardiovascular system

abnormal heart morphology ( J:211773 )

♂

IMPC - UCD

increased heart atrium size ( J:211773 )

♂

IMPC - UCD

increased heart weight ( J:211773 )

♂

IMPC - UCD

growth/size/body

increased heart weight ( J:211773 )

♂

IMPC - UCD

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

♀

IMPC - UCD

increased circulating aspartate transaminase level ( J:211773 )

♀

IMPC - UCD