Phenotypes associated with this allele

• Allele Symbol: Tg(RP23-352G18)1Coppa
• Allele Name: transgene insertion 1, Roberto Coppari
• Allele ID: MGI:5696226
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(RP23-352G18)1Coppa/0	C57BL/6-Tg(RP23-352G18)1Coppa	MGI:5750462

Genotype
MGI:5750462

tg1

• Allelic Composition: Tg(RP23-352G18)1Coppa/0
• Genetic Background: C57BL/6-Tg(RP23-352G18)1Coppa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased susceptibility to diet-induced obesity ( J:229077 )

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:229077 )

decreased circulating glucose level ( J:229077 )

• reduced basal (non-postprandial) glucose levels in 16 week old mice as compared to wild-type

• reduction occurs on both standard chow and high caloric diet (HCD)

improved glucose tolerance ( J:229077 )

• improved intraperitoneal glucose tolerance in 11-13 week old mice on chow diet as compared to wild-type

• improved intraperitoneal glucose tolerance in 18-20 week old mice on high calorie diet as compared to wild-type

increased insulin sensitivity ( J:229077 )

• enhanced insulin sensitivity in skeletal muscle and liver as compared to wild-type

• increased insulin-stimulated glucose uptake in gastrocnemius and soleus muscle, but not in brain, interscapular brown adipose or epididymal adipose tissue

decreased susceptibility to diet-induced non-insulin dependent diabetes ( J:229077 )