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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dbx1tm2Jcor
targeted mutation 2, Joshua Corbin
MGI:5696633
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dbx1tm2Jcor/Dbx1tm2Jcor involves: 129S1/Sv * 129X1/SvJ MGI:5697927
cn2
Dbx1tm2Jcor/Dbx1tm1Tmj
Tg(Nkx2-1-cre)2Sand/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5697928


Genotype
MGI:5697927
hm1
Allelic
Composition
Dbx1tm2Jcor/Dbx1tm2Jcor
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbx1tm2Jcor mutation (1 available); any Dbx1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile




Genotype
MGI:5697928
cn2
Allelic
Composition
Dbx1tm2Jcor/Dbx1tm1Tmj
Tg(Nkx2-1-cre)2Sand/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbx1tm1Tmj mutation (1 available); any Dbx1 mutation (25 available)
Dbx1tm2Jcor mutation (1 available); any Dbx1 mutation (25 available)
Tg(Nkx2-1-cre)2Sand mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• attenuated response to predator (rat) odor is observed in females ( as measured by corticosterone levels in the lateral hypothalamus area) as compared to control females
• males (either control or mutant) do not exhibit a response
• slices from the lateral hypothalamic area (LH) exhibit 85% lower spike density in low glucose
• slices from the lateral hypothalamic area (LH) exhibit 50% lower average spike frequency in high glucose
• however, glucose tolerance is not affected

behavior/neurological
• females exhibit a similar response following presentation with either rat or benign odor in contrast to controls
• females exhibit fewer and shorter escape behaviors as compared to controls following presentation with rat odor
• females eat less than controls on a restricted diet
• decrease in amount of food consumed following a 12 hour fast is observed in females, but not males
• however, daily food consumption is similar to controls
• activity, as determined by horizontal line crossings, is increased in males, but not in females

growth/size/body
• decreased body weight in males, but not females, is observed after weaning
• females exhibit a decrease in body weight under restricted or high fat diets

adipose tissue
• males exhibit decrease in body fat composition after 7 weeks on high fat diet





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory