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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hmmrtm1Plou
targeted mutation 1, Aspasia Ploubidou
MGI:5696779
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hmmrtm1Plou/Hmmrtm1Plou involves: C57BL/6 * C57BL/6J MGI:5696781


Genotype
MGI:5696781
hm1
Allelic
Composition
Hmmrtm1Plou/Hmmrtm1Plou
Genetic
Background
involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmmrtm1Plou mutation (0 available); any Hmmr mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• at 10 weeks of age
• more so at 26 weeks of age
• abnormal spindle orientation in granulosa cells

reproductive system
N
• oocyte meiotic maturation is normal
• at 10 weeks of age
• more so at 26 weeks of age
• abnormal spindle orientation in granulosa cells
• abnormal spindle orientation
• 5-fold at 10 weeks of age
• however, primordial follicles are normal at P7
• due to a defect from primordial to primary follicle
• age-dependent hypofertility with a progressive decrease in number of offspring per litter after 24 weeks of age
• however, the total number of litters born over 6 months is normal
• age-dependent hypofertility with a progressive decrease in number of offspring per litter after 24 weeks of age

endocrine/exocrine glands
• abnormal spindle orientation
• 5-fold at 10 weeks of age
• however, primordial follicles are normal at P7
• due to a defect from primordial to primary follicle





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory