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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hmmrtm1Plou
targeted mutation 1, Aspasia Ploubidou
MGI:5696779
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hmmrtm1Plou/Hmmrtm1Plou involves: C57BL/6 * C57BL/6J MGI:5696781


Genotype
MGI:5696781
hm1
Allelic
Composition		 Hmmrtm1Plou/Hmmrtm1Plou
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmmrtm1Plou mutation (0 available); any Hmmr mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased oocyte number ( J:221355 )
• at 10 weeks of age
• more so at 26 weeks of age
abnormal meiotic spindle morphology ( J:221355 )
• abnormal spindle orientation in granulosa cells

reproductive system
reproductive system phenotype ( J:221355 )
N
• oocyte meiotic maturation is normal
decreased oocyte number ( J:221355 )
• at 10 weeks of age
• more so at 26 weeks of age
abnormal meiotic spindle morphology ( J:221355 )
• abnormal spindle orientation in granulosa cells
abnormal granulosa cell morphology ( J:221355 )
• abnormal spindle orientation
decreased primary ovarian follicle number ( J:221355 )
• 5-fold at 10 weeks of age
• however, primordial follicles are normal at P7
impaired ovarian folliculogenesis ( J:221355 )
• due to a defect from primordial to primary follicle
reduced female fertility ( J:221355 )
• age-dependent hypofertility with a progressive decrease in number of offspring per litter after 24 weeks of age
• however, the total number of litters born over 6 months is normal
decreased litter size ( J:221355 )
• age-dependent hypofertility with a progressive decrease in number of offspring per litter after 24 weeks of age

endocrine/exocrine glands
abnormal granulosa cell morphology ( J:221355 )
• abnormal spindle orientation
decreased primary ovarian follicle number ( J:221355 )
• 5-fold at 10 weeks of age
• however, primordial follicles are normal at P7
impaired ovarian folliculogenesis ( J:221355 )
• due to a defect from primordial to primary follicle




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory