Phenotypes associated with this allele

• Allele Symbol: D130043K22Rik^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5696928
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	D130043K22Rik^tm1b(KOMP)Wtsi/D130043K22Rik^tm1b(KOMP)Wtsi	C57BL/6N-D130043K22Rik^tm1b(KOMP)Wtsi/Ucd	MGI:6262244
hm2	D130043K22Rik^tm1b(KOMP)Wtsi/D130043K22Rik^tm1b(KOMP)Wtsi	involves: C57BL/6 * CBA	MGI:6112643
ht3	D130043K22Rik^tm1b(KOMP)Wtsi/D130043K22Rik^+	involves: C57BL/6 * CBA	MGI:6112644

Genotype
MGI:6262244

hm1

• Allelic Composition: D130043K22Rik^{tm1b(KOMP)Wtsi}/D130043K22Rik^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-D130043K22Rik^{tm1b(KOMP)Wtsi}/Ucd
• Cell Lines: EPD0077_5_D04

Data Sources

IMPC Data for D130043K22Rik

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased mean corpuscular volume ( J:211773 )

♀

IMPC - UCD

Genotype
MGI:6112643

hm2

• Allelic Composition: D130043K22Rik^{tm1b(KOMP)Wtsi}/D130043K22Rik^{tm1b(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * CBA

behavior/neurological

behavior/neurological phenotype ( J:241324 )

N • normal activity in 1-hour open field test

N • normal social interaction and response to social novelty in 3-chamber apparatus

N • normal locomotor behavior and motor coordination and balance

N • normal spatial learning, working memory and reference memory

N • normal learning, memory and conditioning

decreased anxiety-related response ( J:241324 )

• spending more time in light area in light/dark box test

cellular

cellular phenotype ( J:241324 )

N • normal cell cycle and mitosis in embryonic brain at E15.5 and E18.5

nervous system

nervous system phenotype ( J:241324 )

N • normal radial glial cell number in brain at E15.5 and E18.5

N • normal cortical wall thickness in telencephalon at E18.5

N • normal telencephalon, cortical plate, dentate gyrus and hippocampus CA1 region morphology at P2 and P10

N • normal cerebellum morphology at E15.5, E18.5 and P10

N • normal prepulse inibition in females

increased prepulse inhibition ( J:241324 )

♂ • in startle responses at long intervals between prepulse and acoustic startle-eliciting stimulus

♂ • normal prepulse inibition in females

Genotype
MGI:6112644

ht3

• Allelic Composition: D130043K22Rik^{tm1b(KOMP)Wtsi}/D130043K22Rik⁺
• Genetic Background: involves: C57BL/6 * CBA

behavior/neurological

behavior/neurological phenotype ( J:241324 )

N • learning, memory and conditioning

N • anxiety related response

N • activity in 1-hour open field test

N • social interaction and response to social novelty in 3-chamber apparatus

N • locomotor behavior and motor coordination and balance

N • spatial learning, working memory and reference memory

nervous system

nervous system phenotype ( J:241324 )

N • radial glial cell number in brain at E15.5 and E18.5

N • cortical wall thickness in telencephalon at E18.5

N • telencephalon, cortical plate, dentate gyrus and hippocampus CA1 region morphology at P2 and P10

N • cerebellum morphology at E15.5, E18.5 and P10

N • prepulse inibition

cellular

cellular phenotype ( J:241324 )

N • cell cycle and mitosis in embryonic brain at E15.5 and E18.5