Phenotypes associated with this allele

• Allele Symbol: Pde6g^{tm1(cre/ERT2)Eye}
• Allele Name: targeted mutation 1, Stephen H Tsang
• Allele ID: MGI:5696992
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Arl13b^tm1.1Tc/Arl13b^tm1.1Tc Pde6g^tm1(cre/ERT2)Eye/Pde6g^+	involves: 129S6/SvEvTac * C57BL/6J	MGI:6382451

Genotype
MGI:6382451

cn1

• Allelic Composition: Arl13b^tm1.1Tc/Arl13b^tm1.1Tc; Pde6g^{tm1(cre/ERT2)Eye}/Pde6g⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal photoreceptor connecting cilium morphology ( J:272501 )

• the photoreceptor axoneme is reduced in length 2 weeks after tamoxifen induction in adults

abnormal photoreceptor outer segment morphology ( J:272501 )

• marker analysis indicates that normal trafficking of outer segment proteins in rod photoreceptors is altered after tamoxifen induction in adults

• accumulation of vesicles is seen within the photoreceptor outer segments after tamoxifen induction in adults

retina photoreceptor degeneration ( J:272501 )

• majority of photoreceptor cells are lost 5 weeks after tamoxifen induction in adults

abnormal electroretinogram waveform feature ( J:272501 )

• mice injected with tamoxifen at P60 for 3 days show a reduction in scotopic (rod) photoresponse at 3 weeks after injections, leading to complete ablation of photoresponse 5 weeks after injections

• mice injected with tamoxifen at P60 for 3 days show a severe reduction in photopic photoresponses 5 weeks after injections

• however, the scotopic photoresponse is unaltered 2 weeks after tamoxifen injection

nervous system

abnormal photoreceptor connecting cilium morphology ( J:272501 )

• the photoreceptor axoneme is reduced in length 2 weeks after tamoxifen induction in adults

abnormal photoreceptor outer segment morphology ( J:272501 )

• marker analysis indicates that normal trafficking of outer segment proteins in rod photoreceptors is altered after tamoxifen induction in adults

• accumulation of vesicles is seen within the photoreceptor outer segments after tamoxifen induction in adults

retina photoreceptor degeneration ( J:272501 )

• majority of photoreceptor cells are lost 5 weeks after tamoxifen induction in adults

cellular

abnormal photoreceptor connecting cilium morphology ( J:272501 )

• the photoreceptor axoneme is reduced in length 2 weeks after tamoxifen induction in adults