Phenotypes associated with this allele

• Allele Symbol: Setx^tm1.1Mfl
• Allele Name: targeted mutation 1.1, Martin F Lavin
• Allele ID: MGI:5697060
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Setx^tm1.1Mfl/Setx^tm1.1Mfl	Not Specified	MGI:5697155

Genotype
MGI:5697155

hm1

• Allelic Composition: Setx^tm1.1Mfl/Setx^tm1.1Mfl
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small testis size and disrupted spermatogenesis in Setx^tm1.1Mfl/Setx^tm1.1Mfl mice

reproductive system

azoospermia ( J:223053 )

♂ • absent of male germ cells and mature sperm

abnormal male meiosis ( J:223053 )

♂ • defective meiotic crossing-over and sex chromosome inactivation

arrest of male meiosis ( J:223053 )

♂ • spermatocyte development arrests at the pachytene stage of meiotic prophase

increased male germ cell apoptosis ( J:223053 )

♂ • elevated male germ cell apoptosis compared with wild-type mice

abnormal seminiferous tubule morphology ( J:223053 )

♂ • severe disruption from 35 days

abnormal seminiferous tubule epithelium morphology ( J:223053 )

♂ • disrupted in some places

small testis ( J:223053 )

♂

abnormal spermiogenesis ( J:223053 )

♂ • germ cells fail to enter spermiogenesis

♂ • however, development from spermatogonia to meiotic pachytene stage is normal

globozoospermia ( J:223053 )

♂

reduced female fertility ( J:223053 )

♀ • very low numbers of viable embryos are produced after mating

♀ • however, mice exhibit normal ovary structure and follicles and the ability to ovulate

male infertility ( J:223053 )

♂ • despite normal secondary sexual characteristics and mechanics of mating

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:223053 )

♂ • persistent double-strand breaks in male germ cells

cellular

azoospermia ( J:223053 )

♂ • absent of male germ cells and mature sperm

globozoospermia ( J:223053 )

♂

abnormal male meiosis ( J:223053 )

♂ • defective meiotic crossing-over and sex chromosome inactivation

arrest of male meiosis ( J:223053 )

♂ • spermatocyte development arrests at the pachytene stage of meiotic prophase

increased male germ cell apoptosis ( J:223053 )

♂ • elevated male germ cell apoptosis compared with wild-type mice

abnormal double-strand DNA break repair ( J:223053 )

♂ • persistent double-strand breaks in male germ cells

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:223053 )

♂ • severe disruption from 35 days

abnormal seminiferous tubule epithelium morphology ( J:223053 )

♂ • disrupted in some places

small testis ( J:223053 )

♂