Phenotypes associated with this allele

• Allele Symbol: Slc39a3^tm1.1Gka
• Allele Name: targeted mutation 1.1, Glen K Andrews
• Allele ID: MGI:5697153
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Slc39a1^tm1.1Gka/Slc39a1^tm1.1Gka Slc39a3^tm1.1Gka/Slc39a3^tm1.1Gka	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3625156

Genotype
MGI:3625156

cx1

• Allelic Composition: Slc39a1^tm1.1Gka/Slc39a1^tm1.1Gka; Slc39a3^tm1.1Gka/Slc39a3^tm1.1Gka
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryo development ( J:108627 )

• 91% of E14 homozygous doubly mutant embryos of dams fed a zinc-deficient diet (<1 ppm Zn) from day E8 are grossly abnormal

embryonic growth retardation ( J:108627 )

• of the abnormal embryos of zinc-deprived doubly mutant dams, the majority (54%) are severely affected, exhibiting craniofacial defects and dramatic retardation of both growth and development

• doubly mutant zinc-deprived E14 embryos classified as mildly affected, i.e., growth retarded with delayed limb development, often have formed no digits on the hind- or forelimbs

growth/size/body

embryonic growth retardation ( J:108627 )

• of the abnormal embryos of zinc-deprived doubly mutant dams, the majority (54%) are severely affected, exhibiting craniofacial defects and dramatic retardation of both growth and development

• doubly mutant zinc-deprived E14 embryos classified as mildly affected, i.e., growth retarded with delayed limb development, often have formed no digits on the hind- or forelimbs

limbs/digits/tail

abnormal limb development ( J:108627 )

• doubly mutant zinc-deprived E14 embryos classified as mildly affected, i.e., growth retarded with delayed limb development, often have formed no digits on the hind- or forelimbs

craniofacial

abnormal craniofacial development ( J:108627 )

• of the abnormal embryos of zinc-deprived doubly mutant dams, the majority (54%) are severely affected, exhibiting craniofacial defects and dramatic retardation of both growth and development

integument

blistering ( J:108627 )

• doubly mutant zinc-deprived E14 embryos classified as mildly affected, i.e., small with delayed limb development, often exhibit a dorsal skin blister; this effect is not observed in wild-type or either singly mutant zinc-deprived embryos