Phenotypes associated with this allele

• Allele Symbol: Dpmy
• Allele Name: deficient peripheral myelin
• Allele ID: MGI:5697177
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dpmy/Dpmy^+	B6NJ;CBA-Dpmy/GrsrJ	MGI:5697187

Genotype
MGI:5697187

ht1

• Allelic Composition: Dpmy/Dpmy⁺
• Genetic Background: B6NJ;CBA-Dpmy/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:226382 )

• heterozygotes can be identified by a whole body tremor by ~3 weeks of age

• fast overall tremor persists when heterozygotes are picked up

• however, gait is fairly normal

hunched posture ( J:226382 )

• heterozygotes become hunched and sickly by ~5 to 9 months of age

reproductive system

reduced fertility ( J:226382 )

• males and females can breed, but have a higher than normal number of non-productive matings indicative of reduced fertility

muscle

muscular atrophy ( J:226382 )

• neurogenic atrophy of some muscle fibers at 11 weeks of age

nervous system

demyelination ( J:226382 )

• histological assessment at 11 weeks of age revealed an absence of peripheral myelin along with neurogenic atrophy of some muscle fibers

mortality/aging

postnatal lethality, incomplete penetrance ( J:226382 )

• of 29 pups born in 6 litters from wild-type x heterozygote or heterozygote x wild-type crosses, 10 were phenotypically identified as mutant at 3 weeks of age and 6 were missing before phenotypic assessment