All Phenotypes Evc2<tm2.1Mis> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Evc2^tm2.1Mis/Evc2^tm2.1Mis Tg(Mpz-cre)94Imeg/0	involves: 129X1/SvJ	MGI:5698050
cn2	Evc2^tm2.1Mis/Evc2^tm2.1Mis Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:5698047
cn3	Evc2^tm2.1Mis/Evc2^tm2.1Mis Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0	involves: 129X1/SvJ * CD-1	MGI:5698049
cn4	Evc2^tm2.1Mis/Evc2^tm2.1Mis Tg(Col2a1-cre/ERT)KA3Smac/0	involves: 129X1/SvJ * FVB/N	MGI:5698048

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

short lower incisors ( J:226455 )

• lower incisors showed slightly shorter length and relatively normal radio density

short upper incisors ( J:226455 )

• upper incisors were shorter than those in control littermates

abnormal tooth development ( J:226455 )

• at E18.5, pre-ameloblasts located in the posterior area of normal upper incisor are less differentiated with fully extended nuclei within ameloblasts

• at E18.5 deposition of extracellular matrix proteins surrounding ameloblasts is reduced

abnormal ameloblast morphology ( J:226455 )

• at E18.5 revealed that ameloblasts in mutant mice did not polarize appropriately when compared to those with control littermates

skeleton

short lower incisors ( J:226455 )

• lower incisors showed slightly shorter length and relatively normal radio density

short upper incisors ( J:226455 )

• upper incisors were shorter than those in control littermates

abnormal tooth development ( J:226455 )

• at E18.5, pre-ameloblasts located in the posterior area of normal upper incisor are less differentiated with fully extended nuclei within ameloblasts

• at E18.5 deposition of extracellular matrix proteins surrounding ameloblasts is reduced

abnormal ameloblast morphology ( J:226455 )

• at E18.5 revealed that ameloblasts in mutant mice did not polarize appropriately when compared to those with control littermates

growth/size/body

short lower incisors ( J:226455 )

• lower incisors showed slightly shorter length and relatively normal radio density

short upper incisors ( J:226455 )

• upper incisors were shorter than those in control littermates

abnormal tooth development ( J:226455 )

• at E18.5, pre-ameloblasts located in the posterior area of normal upper incisor are less differentiated with fully extended nuclei within ameloblasts

• at E18.5 deposition of extracellular matrix proteins surrounding ameloblasts is reduced

abnormal ameloblast morphology ( J:226455 )

• at E18.5 revealed that ameloblasts in mutant mice did not polarize appropriately when compared to those with control littermates

mortality/aging

mortality/aging ( J:226455 )

N	• did not notice lethality in the neural crest-specific mutant mice during the period of observation (up to 6 months)

Allelic Composition	Evc2^tm2.1Mis/Evc2^tm2.1Mis Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Evc2^tm2.1Mis mutation (0 available); any Evc2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

disproportionate dwarf ( J:226455 )

• disproportionally shorter forelimbs and hindlimbs are seen

Allelic Composition	Evc2^tm2.1Mis/Evc2^tm2.1Mis Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background	involves: 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Evc2^tm2.1Mis mutation (0 available); any Evc2 mutation (47 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:226455 )

N	• no overt differences in body weight compared to controls

skeleton

skeleton phenotype ( J:226455 )

N	• no overt phenotypes in skeletal system at 6 months after birth compared to controls • no overt differences in lengths of long bones compared to controls and no overt changes in trabecular components and cortical components of tibia

Allelic Composition	Evc2^tm2.1Mis/Evc2^tm2.1Mis Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background	involves: 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Evc2^tm2.1Mis mutation (0 available); any Evc2 mutation (47 available)
Tg(Col2a1-cre/ERT)KA3Smac mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

disproportionate dwarf ( J:226455 )

• skeletal staining with alizarin red and alcian blue indicated a decrease of limb length

limbs/digits/tail

short humerus ( J:226455 )