Phenotypes associated with this allele

• Allele Symbol: Elfn1^tm1.1Jaru
• Allele Name: targeted mutation 1.1, Jun Aruga
• Allele ID: MGI:5697443
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elfn1^tm1.1Jaru/Elfn1^tm1.1Jaru	involves: C57BL/6	MGI:5697457

Genotype
MGI:5697457

hm1

• Allelic Composition: Elfn1^tm1.1Jaru/Elfn1^tm1.1Jaru
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:226212 )

• mice show increased susceptibility to pentylenetetrazone (PTZ) induced seizures than wild-type mice, with 92% developing seizures compared to 57% of wild-type mice and with shorter latency to generalized seizure

abnormal response to novelty ( J:226212 )

• in the hole board test, mice show prolonged latencies to dipping their heads into all holes, whereas the total number of head dips does not differ

abnormal impulsive behavior control ( J:226212 )

• in the elevated plus maze, mice spend a longer time in the open arms and show more entries into the open arms, however mice do not show reduced anxiety in the light-dark box test, suggesting increased impulsivity rather than reduced anxiety

decreased vertical activity ( J:226212 )

• in the hole board test, mice show a lower total time of rearing

hyperactivity ( J:226212 )

• mice show increased activity in home cages, mainly in the dark phase

• in the forced swimming test, mice show reduced immobility time

• however, mice show normal prepulse inhibition and pain sensitivity

increased locomotor activity ( J:226212 )

• in the light-dark box transition test, the total distance travelled and total number of transitions are larger in mutants

• mice show increased total distance traveled in the elevated plus maze and hole board tests

environmentally induced seizures ( J:226212 )

• mice exhibit epileptic seizures during routine handling

• handling seizures are seen beginning at 11 weeks of age and the percentage of affected mice peaks (at about 80%) at 5 months

nervous system

increased susceptibility to pharmacologically induced seizures ( J:226212 )

• mice show increased susceptibility to pentylenetetrazone (PTZ) induced seizures than wild-type mice, with 92% developing seizures compared to 57% of wild-type mice and with shorter latency to generalized seizure

environmentally induced seizures ( J:226212 )

• mice exhibit epileptic seizures during routine handling

• handling seizures are seen beginning at 11 weeks of age and the percentage of affected mice peaks (at about 80%) at 5 months

abnormal dendritic spine morphology ( J:226212 )

• small but significant decrease in GluR1a-positive spine density at 4 months of age

abnormal brain wave pattern ( J:226212 )

• EEG activity indicates the presence of frequent sharp waves not seen in wild-type mice

impaired synaptic plasticity ( J:226212 )

• impaired presynaptic form of plasticity

abnormal excitatory postsynaptic currents ( J:226212 )

• synapses do not show facilitation and the 3rd, 4th, and 5th excitatory postsynaptic currents (EPSCs) are depressed indicating impaired short-term plasticity at excitatory synapses onto oriens lacunosum moleculare neurons

• however, short-term plasticity of synaptic inputs to pyramidal neurons are normal

reduced long-term potentiation ( J:226212 )

• LTP at pyramidal neuron- onto oriens lacunosum moleculare neuron synapses is impaired

increased synaptic depression ( J:226212 )

• a brief train of afferent stimulation induces short-term depression rather than short-term facilitation at CA1 pyramidal neuron- onto oriens lacunosum moleculare neuron synapses